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David J. Schreyer, Director
Associate Professor
Department of Anatomy and Cell Biology
B.A. (1977) Johns Hopkins University
Ph.D. (1986) Washington University
Research in Dr. Schreyer's lab examines the
metabolic response that neurons undergo following injury, and
how this response contributes to an ability to regenerate damaged
nerve fibers. For example, GAP-43 is one of several proteins
whose altered synthesis correlates with growth potential.Experimental
work indicates that some aspect of the interaction of neurons
with the target cells that they contact controls growth-associated
gene expression. Tissue culture methods are being used to trace
the steps in this signalling pathway. If these cell-cell signals
can be artificially manipulated, it may be possible to induce
normally recalcitrant neurons to undergo the required changes
in gene expression, and to regenerate their damaged axons following
CNS injury.
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