For Additional Information Contact:

World Health Organization
Collaborating Centre for Research and Training in
 Stroke Prevention, Epidemiology and Surveillance

The Altschul Symposium Fund;

Disease Prevention Division, Health Canada;

Laboratory Centre for Disease Control (LCDC), Health Canada;

Saskatchewan Stroke Research Centre;

World Health Organization;

Health and Stroke Foundation of Saskatchewan.

1. Develop a cohort of professionals to work toward the integration of basic mechanisms
into stroke prevention  both in Canada and internationally.

2. Facilitate networking and linkages between individuals examining the basic mechanisms
of stroke and those providing clinical stroke care both in Canada and internationally.

Examine the role of inflammation in the pathogenesis of stroke.

Identify potential preventative and therapeutic interventions that
may alter inflammatory processes in stroke.

Examine the role of nutritional factors in the pathogenesis of stroke.

Review current dietary intakes of relevant nutritional factors in both
the general population and those individuals who have suffered a stroke.

Develop an understanding of effective methods of nutritional intervention
in the prevention and treatment of stroke.

Develop an understanding of the impact that policy has on changing
dietary habits at the levels of the population and the individual.

Consider new ways of integrating basic mechanisms into a
National Systems Approach to stroke prevention and care.

WEDNESDAY, AUGUST 18, 1999  - Opening

*  Dinner and Official Opening of the 5th Altschul Symposium
    and the 4th Annual WHO Summer School

        * Neuroinflammation: cellular mechanisms and mediators
                    - G.Z. Feuerstein
                                   DuPont Pharmaceutical Company
                             Wilmington, DE, U.S.A.

        * Trauma results in rapid onset of oxidative stress
                    - H. Kamencic
                      University of Saskatchewan
                                   Saskatoon, SK, Canada

        * Mediators and Functions of neuroinflammation
           following CNS trauma
                    - V.W. Yong
                      University of Calgary
                                   Calgary, AB, Canada

        * Inflammation in the ischemic brain
                    - K. Kogure
                      Foundation for Brain Function & Diseases
                                   Fukaya, Saitama, Japan

        * Microglial responses to ischemia-like conditions
                    - W. Walz
                      University of Saskatchewan
                                   Saskatoon, SK, Canada

        * Inflammatory lung disease
                    - P. Ward
                      University of Michigan
                                   Ann Arbor, MI, U.S.A.

        * Social and BBQ

FRIDAY, AUGUST 20, 1999 - Day 2
      NEURO-INFLAMMATION
      Cellular Mechanisms and Mediators

   * Leukocyte - endothelium interactions
               - P. Kubes
                 University of Calgary
                           Calgary, AB, Canada

   * Role of endothelium and astrocytes in
     ischemia-induced inflammation
               - D. Stanimirovic
                 National Research Council
                           Ottawa, ON, Canada

  * Role of eicosanoids and nitric oxide in
    post-ischemic inflammation
               - C. Iadecola
                 University of Minnesota
                           Minneapolis, MN, U.S.A.

  * Platelet-activating factor and stroke
               - K. Satoh
                 Hirosaki University
                           Hirosaki, Japan

  * Mechanisms of axonal degeneration after spinal cord
   injury: role of inflammatory mediators
               - M. Fehlings
                 The Toronto Hospital
                           Toronto, ON, Canada

  * Analysis of neuroinflammation using cDNA microarrays
               - K. Becker
                 National Institutes of Health
                           Bethesda, MD, U.S.A.

  * Dinner

  * Poster session

  * Current clinical strategies: pharmacological and
    non-pharmacological
               - T. DeGraba
                 National Institutes of Health
                           Bethesda, MD, U.S.A.

  * Problems associated with reperfusion
               - G. Del Zoppo
                 The Scripps Research Institute
                            La Jolla, CA, U.S.A.

  * The potential of hypothermia in stroke therapy
               - S. Schwab
                 Heidelberg University
                           Heidelberg, Germany

       * Inhibition of NF-6B activation: A new target for
           prevention of multi-organ inflammation
                    - J.W. Christman
                      Vanderbilt University
                                   Nashville, TN, U.S.A.

       * Phase II enzyme induction as a therapeutic approach
                    - B.H.J. Juurlink
                      University of Saskatchewan
                                   Saskatoon, SK, Canad

       * Wanuskewin Heritage Park and Banquet
 

SUNDAY, AUGUST 22, 1999 - Day 4
      NUTRITION AND STROKE
      Chair: A. Chockalingam

       * Micronutrients and Stroke
                    - D. Spence
                      The John P. Roberts Research Institute
                                   London, ON, Canada

       * Sodium, protein and stroke
                    - Y. Yamori
                      Kyoto University
                                   Kyoto, Japan

       * Minerals and stroke
                    - P. Paterson
                      University of Saskatchewan
                                   Saskatoon, SK, Canada

       * Dietary fat and stroke
                    - S. Jabbour
                      Harvard University
                                   Boston, MA, U.S.A.
                                - A.M. Stephen
                      University of Saskatchewan
                                   Saskatoon, SK, Canada

       * Panel Discussion - Implications for stroke
            prevention, therapy and research

MONDAY, AUGUST 23, 1999 - Day 5 & Closing
      BASIC MECHANISMS IN ISCHEMIA
      Chair: B. Reeder

       * Cerebral artery thrombosis and thrombolysis
                    - P. Teal
                      Vancouver Hospital and Health Sciences Centre
                                   Vancouver, BC, Canada

       * Neurochemistry in ischemia
                    - A. Shuaib
                      University of Alberta
                                   Edmonton, AB, Canada

       * Integrating research and management of basic mechanisms
         into a Systems Approach to stroke care
                    - G. Taylor
                      Health Canada -LCDC
                                   Ottawa, ON, Canada

                    - S. Phillips
                      Dalhousie University
                                   Halifax, NS, Canada

       * Panel Discussion  - What do new developments imply
                             and can we provide them?

       * Official Closure of the Fourth WHO Summer School.
 

• Maximum of 180 participants

• Before July 1, 1999:  $200.00 Cdn.
• After  July 1, 1999:  $250.00 Cdn.
• Resident, Fellow, and Students  Free of Charge  (letter from Supervisor to verify status)

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