Selected Research Papers

Recent Papers by topic:

Nanotechnology
Biomaterials
Protein delivery systems
Gene delivery systems
Vaccine delivery systems
Small molecule delivery systems
Drug targeting
Delivery mechanisms and reviews

Nanotechnology:

Foldvari, M., Badea, I., Wettig, S.D., Verrall, R., Bagonluri, M. (2005) Structural characterization of novel gemini non-viral DNA delivery systems for cutaneous gene therapy. J. Exp. Nanosci. (in press)

Biomaterials:

Li, X., Wettig, S.D., Badea, I., Foldvari, M. & Verrall, R. (2005) Synthesis and solution properties of gemini surfactants containing oleyl chains. Phys. Chem. Chem. Phys. 7:1-7.

Protein delivery systems:

King,M. J., Michel, D., Foldvari M. (2003) Evidence for lymphatic transport of insulin by topically applied biphasic vesicles. J Pharm Pharmacol 55, 1339-44.

King, M. J., Badea, I., Solomon, J., Kumar, P., Gaspar, K. J. & Foldvari, M. (2002). Transdermal delivery of insulin from a novel biphasic lipid system in diabetic rats. Diabetes Technol Ther 4, 479-88.

Foldvari, M., Baca-Estrada, M. E., He, Z., Hu, J., Attah-Poku, S. & King, M. (1999). Dermal and transdermal delivery of protein pharmaceuticals: lipid-based delivery systems for interferon alpha. Biotechnol Appl Biochem 30 ( Pt 2), 129-37.

Foldvari, M., Attah-Poku, S., Hu, J., Li, Q., Hughes, H., Babiuk, L. A. & Kruger, S. (1998). Palmitoyl derivatives of interferon alpha: potential for cutaneous delivery. J Pharm Sci 87, 1203-8.

Gene delivery systems:

Foldvari, M., Kumar, P., King, M., Batta, R., Michel, D., Badea, I., Wloch, M. (2005) Gene delivery into human skin in vitro using biphasic lipid vesicles. Curr. Drug Deliv. (in press)

Badea, I., Verrall, R., Tikoo, S., Baca-Estrada, M. E., Rosenberg, A., Kumar, P., Foldvari, M. (2005) In vivo cutaneous interferon-? gene delivery using novel dicationic (gemini) surfactant – plasmid complexes. J. Gene Med. 7:1200-1214.

Babiuk, S., Baca-Estrada, M. E., Pontarollo, R. & Foldvari, M. (2002). Topical delivery of plasmid DNA using biphasic lipid vesicles (Biphasix™). J Pharm Pharmacol 54, 1609-14.

Babiuk, S., Baca-Estrada, M. E., Foldvari, M., Storms, M., Rabussay, D., Widera, G. & Babiuk, L. A. (2002). Electroporation improves the efficacy of DNA vaccines in large animals. Vaccine 20, 3399-3408.

Babiuk, L. A., Lewis, J., Suradhat, S., Baca-Estrada, M., Foldvari, M. & Babiuk, S. (1999). Polynucleotide vaccines: potential for inducing immunity in animals. J Biotechnol 73, 131-40.

Vaccine delivery systems:

Alcón, V.L., Vega-López, M.A., Baca-Estrada, M.E., Willson, P., Babiuk, L.A., Hecker, R., Kumar, P. and Foldvari, M. (2005) Mucosal delivery of bacterial antigens and CpG ODN formulated in biphasic lipid vesicles in pigs. The AAPS Journal (in press)

Alcón, V.L., Baca-Estrada, M.E., Potter, A., Babiuk, L.A., Kumar, P. and Foldvari, M. (2005) Biphasic lipid vesicles as delivery systems for protein antigens and CpG ODN. Curr. Drug Del. (in press)

Alcón, V.L., Baca-Estrada, M. , Vega-López, M.A., Willson, P., Babiuk, L.A., Kumar, P. and Foldvari, M. (2005) Intranasal immunization using biphasic lipid vesicles as delivery systems for OmlA bacterial protein antigen and CpG oligonucleotides adjuvant in a mouse model. J. Pharm. Pharmacol. 57:955-962.

Babiuk,S., Baca-Estrada, M. E., Middleton, D. M., Hecker, R., Babiuk, L. A. and Foldvari, M. (2004) Biphasic Lipid Vesicles (Biphasix™) Enhance The Adjuvanticity of CpG Oligo-nucleotides Following Systemic and Mucosal Administration. Curr Drug Deliv 1, 9-15.

Babiuk, S., Baca-Estrada, M. E., Foldvari, M., Baizer, L., Stout, R., Storms, M., Rabussay, D., Widera, G., and Babiuk, L.A. (2003) Needle-free Topical Electroporation Improves Gene Expression from Plasmids Administered in Porcine Skin. Mol Ther 8, 992-998.

Alcon, V. L., Foldvari, M., Snider, M., Willson, P., Gomis, S., Hecker, R., Babiuk, L. A. & Baca-Estrada, M. E. (2003). Induction of protective immunity in pigs after immunisation with CpG oligodeoxynucleotides formulated in a lipid-based delivery system (Biphasix). Vaccine 21, 1811-4.

Baca-Estrada, M. E., Ewen, C., Mahony, D., Babiuk, L. A., Wilkie, D. & Foldvari, M. (2002). The haemopoietic growth factor, Flt3L, alters the immune response induced by transcutaneous immunization. Immunology 107, 69-76.

Baca-Estrada, M. E., Foldvari, M., Babiuk, S. L. & Babiuk, L. A. (2000). Vaccine delivery: lipid-based delivery systems. J Biotechnol 83, 91-104.

Babiuk, S., Baca-Estrada, M., Babiuk, L. A., Ewen, C. & Foldvari, M. (2000). Cutaneous vaccination: the skin as an immunologically active tissue and the challenge of antigen delivery. J Control Release 66, 199-214.

Baca-Estrada, M. E., Foldvari, M. M., Snider, M. M., Harding, K. K., Kournikakis, B. B., Babiuk, L. A. & Griebel, P. P. (2000). Intranasal immunization with liposome-formulated Yersinia pestis vaccine enhances mucosal immune responses. Vaccine 18, 2203-11.

Papp, Z., Middleton, D. M., Rontved, C. M., Foldvari, M., Gordon, J. R. & Baca-Estrada, M. E. (2000). Transtracheal administration of interleukin-12 induces neutrophil responses in the murine lung. J Interferon Cytokine Res 20, 191-5.

Baca-Estrada, M. E., Foldvari, M., Ewen, C., Badea, I. & Babiuk, L. A. (2000). Effects of IL-12 on immune responses induced by transcutaneous immunization with antigens formulated in a novel lipid-based biphasic delivery system. Vaccine 18, 1847-54.

Baca-Estrada, M. E., Foldvari, M. & Snider, M. (1999). Induction of mucosal immune responses by administration of liposome-antigen formulations and interleukin-12. J Interferon Cytokine Res 19, 455-62.

Baca-Estrada, M. E., Foldvari, M., Snider, M., van Drunen Littel-van den Hurk, S. & Babiuk, L. A. (1997). Effect of IL-4 and IL-12 liposomal formulations on the induction of immune response to bovine herpesvirus type-1 glycoprotein D. Vaccine 15, 1753-60.

Small molecule delivery systems:

Foldvari, M., Jaafari, M. R., Radhi, J. (2005) Efficacy of the anti-adhesin, 2-O-propyl-octyl-beta-Gal NAc (1-4) beta-Gal (Fimbrigal-P) in a rat oral Candidiasis model. Antimicrob. Agents Chemother. 49:2887-2894.

Foldvari, M., Radhi, J., Yang, G., He, Z., Rennie, R. & Wearley, L. (2000). Acute vaginal candidosis model in the immunocompromized rat to evaluate delivery systems for antimycotics. Mycoses 43, 393-401.

Foldvari, M. & Oguejiofor, C. (1999) In Vitro Transdermal delivery and stability of liposome-encapsulated prostaglandins E₁. Int J Pharm Compounding 3, 160-163.

Foldvari, M., Wilson, T.W., Afridi, S.K., Kudel T. & Quest, D.W. (1998) A randomized, double-blind, crossover, placebo-controlled study of a novel topical lipid-based delivery system of prostaglandin E1 in the treatment of erectile failure. Sexual Dysf, 1, 99-104.

Foldvari, M., Oguejiofor, C., Afridi, S., Kudel, T. & Wilson, T. (1998). Liposome encapsulated prostaglandin E1 in erectile dysfunction: correlation between in vitro delivery through foreskin and efficacy in patients. Urology 52, 838-43.

Foldvari, M., Oguejiofor, C. J., Wilson, T. W., Afridi, S. K. & Kudel, T. A. (1998). Transcutaneous delivery of prostaglandin E1: in vitro and laser doppler flowmetry study. J Pharm Sci 87, 721-5.

Foldvari, M. & Moreland, A. (1997.) Clinical observations in the topical liposome-encapsulated interferon alpha for the treatment of genital papillomavirus infections. J Liposome Res 7, 115-126.

Foldvari, M. & Oguejiofor, C. J. (1997). Metabolism studies on transdermal prostaglandin E1 in human foreskin in vitro. Eur J Drug Metab Pharmacokinet 22, 111-20.

Drug targeting:

Jaafari, M. R. & Foldvari, M. (2002). Targeting of liposomes to human keratinocytes through adhesive peptides from immunoglobulin domains in the presence of IFN-gamma. Drug Deliv 9, 1-9.

Jaafari, M. R. & Foldvari, M. (2002). Targeting of liposomes to melanoma cells with high levels of ICAM-1 expression through adhesive peptides from immunoglobulin domains. J Pharm Sci 91, 396-404.

Jaafari, M. R. & Foldvari, M. (1999). P0 protein mediated targeting of liposomes to melanoma cells with high level of ICAM-1 expression. J Drug Target 7, 101-12.

Foldvari, M., Jaafari, M. R., Mezei, M. & Mezei, C. (1998) Targeting liposome through immunoglobulin superfamily domains: (P_o) protein as model. Drug Deliv, 5, 1-13.

Delivery mechanisms and reviews:

Foldvari, M. (2005) Biphasic lipid vesicles. Exp. Opin. Drug Deliv. Invited review, in press

Foldvari, M., Babiuk, S., and I. Badea, I. (2005) DNA delivery for vaccination and therapeutics through the skin. Curr. Drug Deliv. (in press)

Cui, Z., Dierling, A., Foldvari, M. (2005) Non-invasive immunization on the skin using DNA vaccine. Curr. Drug Deliv. (in press)

Foldvari, M. (2000). Non-invasive administration of drugs through the skin: challenges in delivery system design. Pharm Sci Tech Today 3, 417-425.

Foldvari M. (1999) Novel delivery systems for biotechnology drugs: Recent progress toward improved therapies. Can J Clin Pharmacol 6, 5-6.

Foldvari, M. (1998) Liposomal delivery systems in modern medicine. Drugs (Gyogyszereink) 48, 162-171.

Foldvari, M. (1996). Effect of vehicle on topical liposomal drug delivery: petrolatum bases. J Microencapsul 13, 589-600.