Dr. J.R. Dimmock

D.Sc., Ph.D. (London), F.C.I.C.
Professor Emeritus of Pharmacy

216 Thorvaldson
Phone: 306-966-6331
Fax: 306-966-6377
jr.dimmock@usask.ca

Dr. Dimmock came to the College from England in 1967 after a four-year stint as a research chemist in the United Kingdom industrial sector. Prior to his retirement and appointment as Professor Emeritus, Dr. Dimmock taught undergraduate courses in Medicinal Chemistry and Drug Design. He received the University of Saskatchewan Students Union Teaching Excellence Award in 1998, and in 2002 was honoured with the appointment of Professor Emeritus of Pharmacy.

  • Research Interests

Chief areas of pharmaceutical interest include design, synthesis and bioevaluation of cyclic and acyclic Mannich bases as candidate cytotoxic and anticancer agents.

Recent research studies involve synthesis of Mannich bases of alpha-ß-unsaturated ketones as cytotoxic agents; X-ray crystallography of bioactive compounds; and design, synthesis and anticonvulsant evaluation of aryl semicarbazones.

  • Recent Publications (see more in Scopus)

J.R. Dimmock, S.G.R. Gunda, S.C. Vashishtha, G.A. Zello, U. Das, K.H. Nienaber, J.P. Stables, T.M. Allen and C.L. Santos, in press. Anticonvulsants Containing the N-(3-Aryl-2-Propenoyl)Amido Pharmacophore, Journal of Enzyme Inhibition and Medicinal Chemistry.

J.R. Dimmock, N.M. Kandepu, U. Das, G.A. Zello and K.H. Nienaber, 2004. Antimycobacterial Arylidenecyclohexanones and Related Mannich Bases, Pharmazie, 59(7), 502-505.

P. Selvakumar, A. Lakshmikuttyamma, M.K. Pasha, M.J. King, D.J.H. Olson, S. Mori, A.R.S. Ross, K. Hayashi, J.R. Dimmock and R.K. Sharma, 2004. N-Myristoyltransferase Inhibitor Protein is Homologous to Heat Shock Cognate Protein 70, Journal of Cellular Biochemistry, 92, 573-578.

P. Selvakumar, A. Lakschmikuttyamma, R. Kanthan, S.C. Kanthan, J.R. Dimmock and R.K. Sharma, 2004. High Expression of Methionine Aminopeptidase 2 in Human Colorectal Adenocarcinomas, Clinical Cancer Research, 10, 2771-2775.

J.R. Dimmock, M. Chamankhah, U. Das, G.A. Zello, J.W. Quail, J. Yang, K.H. Nienaber, R.K. Sharma, P. Selvakumar, J. Balzarini, E. DeClercq and J.P. Stables, 2004. Cytotoxic and Topographical Properties of 6-Arylidene-2-Dimethylaminomethylcyclohexanone Hydrochlorides and Related Compounds, Journal of Enzyme Inhibition and Medicinal Chemistry, 19(1), 1-10.

S.C. Vashishtha, G.A. Zello, K.H. Nienaber, J. Balzarini, E. DeClercq, J.P. Stables and J.R. Dimmock, 2004. Cytotoxic and Anticonvulsant Aryloxyaryl Mannich Bases and Related Compounds, European Journal of Medicinal Chemistry, 39(1), 27-35.

E.O. Oloo, J.W. Quail, M.P. Padmanilayam, U. Das and J.R. Dimmock, 2004. Cis-3-Phenyl-3,3a,4,4a-tTetrahydrobenzo[g] Indazole-2-Carboxylic Acid Amide, Acta Crystallographica, G60, 610-612.

M.K. Pasha, P. Selvakumar, L. Ashakumary, M. Qureshi, J.R. Dimmock, R.L. Felsted, C.J. Glover and R.K. Sharma, 2004. Lipidic Inhibitors of Human N-Myristoyltransferase, International Journal of Molecular Medicine, 13(4), 557-563.

S. Gowda, A. Shrivastav, P. Selvakumar, J.R. Dimmock and R.K. Sharma, 2004. A Novel Inhibitor Protein of N-myristoyltransferase from Escherichia coli, Biochemical and Biophysical Research Communications, 314, 984-987.

A. Shrivastav, M.K. Pasha, P. Selvakumar, S. Gowda, D.J.H. Olso, A.R.S. Ross, J.R. Dimmock and R.K. Sharma, 2003. Potent Inhibitor of N-Myristoylation: A Novel Molecular Target for Cancer, Cancer Research, 63, 7975-7978.

A. Jha and J.R. Dimmock, 2003. Syntheses of 4-(3,5-Bisphenylmethylene-4-Oxo-Piperidine-1-yl)-4-Oxo-But-2Z-Enoic Acid Arylamides as Candidate Cytotoxic Agents, Synthetic Communications, 33(7), 1211-1223.

J.R. Dimmock, A. Jha, G.A. Zello, R.K. Sharma, A. Shrivastav, P. Selvakumar, T.M. Allen, C.L. Santos, J. Balzarini, E. DeClercq, E.K. Manavathu and J.P. Stables, 2003. 3,5-Bis(Phenylmethylene)-1- (N-Arylmaleamoyl)-4-Piperidones: A Novel Group of Cytotoxic Agents, Journal of Enzyme Inhibition and Medicinal Chemistry, 18(4), 325-332.

S.N. Pandeya and J.R. Dimmock, 1997. An Introduction to Drug Design, New Age International (P) Limited, Publishers, New Delhi.

  • Patents

J.R. Dimmock, 1998. Semicarbazones Having CNS Activity and Pharmaceutical Preparations Containing Same, US 5,741,818.

J.R. Dimmock, O.A. Phillips and R.A. Hickie, 1998. Aminostyryl Ketones, CAN 1,339,743.

  • Research Category Keywords

Medicinal Chemistry