Dr. Ed KrolB.Sc.(Honors) (McMaster), Ph.D. (Queen's)
Associate Professor of Pharmacy and Pharmacy Graduate Chair
3D01.12 Health Sciences
Dr. Krol joined the College in July 2001.
Medicinal Chemistry and Drug Metabolism.
Xenobiotic metabolism and protective properties of naturally occurring polyphenols.
My research group is interested in the properties of lignans and flavonols. Specifically we seek to understand the underlying chemistry responsible for both their chemopreventive and toxicological properties. Flaxseed lignans are believed to be responsible for a number of beneficial health effects including reduction in LDL cholesterol, mammary and colon cancer and Type II diabetes. We plan to investigate the reactions that mammalian lignans derived from flaxseed undergo during oxidative stress to determine how these lignans contribute to chemoprevention. The lignan NDGA is closely related in structure to the flaxseed lignans, yet NDGA use has been associated with kidney toxicity. Our group will study how the subtle differences in lignan structure can influence the reactivity of these compounds. We are also investigating the photo-protective properties of flavonols and have developed mass spectrometric analytical methods to aid in this work.
Recent Publications (see more on Scopus)
Vetter, N.D., Langill, D.M., Anjum, S., Boisvert-Martel, J., Jagdhane, R.C., Omene, E., Zheng, H., Van Straaten, K.E., Asiamah, I., Krol, E.S., Sanders, D.A.R., Palmer, D.R.J. A previously unrecognized kanosamine biosynthesis pathway in Bacillus subtilis (2013) Journal of the American Chemical Society, 135 (16), pp. 5970-5973.
Sabia Maini, Heather L. Hodgson and Ed S. Krol, 2012. The UVA and aqueous stability of flavonoids is dependent on B-ring substitution. Journal of Agricultural and Food Chemistry. http://dx.doi.org/10.1021/jf3016128.
Farah S. Hosseinian, Ed S. Krol and B. David Oomah, 2012. Bioactivity of Flaxseed Lignans. In Understanding Plant Bioactives in Food Systems. Florence O. Uruakpa, Ed.
Ed S. Krol and Lisa M. Krol, 2012. Referencing and Citation for Graduate Students: Gain Without Pain. Canadian Journal for the Scholarship of Teaching and Learning. In press.
Jennifer Billinsky, Katherine Maloney, Ed Krol and Jane Alcorn, 2011. A Comparison Between Lignans from Creosote Bush and Flaxseed and Their Potential to Inhibit Cytochrome P450 Enzyme Activity. In Drug Discovery Research in Pharmacognosy, 145-164, Omboon Vallisuta, Suleiman M. Olomat, Ed.
Brian M. Fahlman and Ed S. Krol, 2009. UVA and UVB Radiation-Induced Oxidation Products of Quercetin, Journal of Photochemistry and Photobiology B: Biology, 97, 123-131.
Brian M. Fahlman and Ed S. Krol, 2009. Inhibition of UVA and UVB radiation-induced lipid oxidation by quercetin, Journal of Agricultural and Food Chemistry, 57 (12), 5301-5305.
Lifeng Chen, Katie Maloney, Ed S. Krol, Anne E. Desjardins and Jian Yang, 2009. Cloning, Overexpression, Purification and Characterization of the Maleylacetate Reductase (PcpE) from Sphingobium chlorophenolicum Strain ATCC 53874, Current Microbiology, 58 (6), 599-603.
Melanie A. Felmlee, Gloria Woo, Elmer Simko, Ed S. Krol, Alister D. Muir and Jane Alcorn, 2009. Effects of the flaxseed lignans secoisolariciresinol diglucoside and its aglycone on serum and hepatic lipids in hyperlipidemic rats. British Journal of Nutrition, 102 (3), 361-369.
Jennifer L. Billinsky,and Ed S. Krol, 2008. Nordihydroguaiaretic Acid Oxidation Produces a Schisandrin-like Dibenzocyclooctadiene Lignan, Journal of Natural Products, 71 (9), 1612-1615.