Dr. Brian Bandy
B.Sc. in Biochemistry (UBC), Ph.D. (Simon Fraser)Associate Professor of Nutrition and Dietetics and Nutrition Graduate Chair
Dr. Bandy joined the College of Pharmacy and Nutrition in 2002, following positions as Research Associate and Postodoctoral Fellow at the University of Sao Paulo, Brazil. He is a member of the Canadian Society of Biochemistry and Molecular & Cell Biology, the Canadian Society for Nutritional Sciences and the Society for Free Radical Biology and Medicine.
Undergraduate courses in Current Issues in Nutrition and Research Methods; contributions to senior Nutrition courses; coordination and team teaching of the graduate course Advances in Human Nutrition Research.
Chief areas of interest are oxidative stress and apoptosis; free radical biochemistry and antioxidant interactions; mitochondrial biogenesis and respiratory activities.
Our research investigates the mechanisms of cellular oxidative stress, and the interactions of antioxidant and pro-oxidant polyphenols such as flavonoids and quinones. We focus on mitochondria, which in addition to generating reactive oxygen species as a byproduct of respiratory activity, are the organelles controlling programmed cell death (apoptosis). We are interested in factors that modulate mitochondrial oxidant generation and damage, with implications for aging and age-related illnesses such as cancer, neurodegenerative disorders, and heart disease.
M.H. Barros, B. Bandy, E.B. Tahara and A.J. Kowaltowski, in press. Higher Respiratory Activity Decreases Mitochondrial Reactive Oxygen Release and Increases Lifespan in Saccharomyces cerevisiae, Journal of Biological Chemistry, 279.
M.E.M. Rocha, F. Dutra, B. Bandy, R.L. Baldini, S.L. Gomes, A. Faljoni-Alario, C.W. Liria, T.M. Miranda and E.J.H. Bechara, 2003. Oxidative Damage to Ferritin by 5-Aminolevulinic Acid, Archives of Biochemistry and Biophysics, 409, 349-356.
B. Bandy and E.J.H. Bechara, 2001. Bioflavonoid Rescue of Ascorbate at a Membrane Interface, Journal of Bioenergetics and Biomembranes, 33, 269-277.
B. Bandy, P.B. Walter, J. Moon and A.J. Davison, 2001. Reaction of Oxygen with 6-Hydroxydopamine Catalyzed by Cu, Fe, Mn and V Complexes: Identification of a Thermodynamic Window for Effective Metal Catalysis, Archives of Biochemistry and Biophysics, 389, 22-30.
A.S-H. Li, B. Bandy, S-S. Tsang and A.J. Davison, 2001. DNA Breakage Induced by 1,2,4-Benzenetriol: Relative Contributions of Oxygen-derived Active Species and Transition Metal Ions, Free Radical Biology & Medicine, 30, 943-956.
A.S-H. Li, B. Bandy, S-S. Tsang and A.J. Davison, 2000. DNA-breaking Versus DNA-protecting Activity of Four Phenolic Compounds In Vitro, Free Radical Research, 33, 551-566.
M.E.M. Rocha, B. Bandy, C.A. Costa, M.P. de Barros, A.P.M. Pinto and E.J.H. Bechara, 2000. Iron Mobilization by Succinylacetone Methyl Ester in Rats: A Model Study for Hereditary Tyrosinemia and Porphyrias Characterized by 5-Aminolevulinic Acid Overload, Free Radical Research, 32, 343-353.
I.L. Nantes, A. Faljoni-Alario, O.R. Nascimento, B. Bandy, R. Gatti and E.J.H. Bechara, 2000. Modifications in Heme Iron of Free and Vesicle Bound Cytochrome C by Tert-Butyl Hydroperoxide: A Magnetic Circular Dichroism and Electron Paramagnetic Resonance Investigation, Free Radical Biology & Medicine, 28, 786-796.