Dr. Phyllis Paterson
B.S.H.Ec., M.Sc.(Sask.), Ph.D.(Guelph)Professor of Nutrition and Dietetics
Dr. Paterson joined the faculty in 1989 following a postdoctoral fellowship at the Hospital for Sick Children Research Institute in Toronto. She is a Principal Investigator at the CAMECO MS Neuroscience Research Center and a Member of the Neural Systems and Plasticity Research Group at the University of Saskatchewan.
Stroke, a reduction in blood flow to a region of the brain, is a major cause of death and disability. Novel treatment strategies are urgently needed. Disease co-morbidity factors such as nutritional status are often neglected in studies of stroke outcome. Thus, my laboratory is studying the effects of clinically relevant nutritional states in experimental models that can link the extent of brain damage and disability to the underlying mechanisms. Our most recent research interests are to investigate how nutrition can enhance recovery mechanisms and rehabilitation strategies after stroke.
Undergraduate course in Clinical Nutrition; team teaches the graduate course Advances in Human Nutritional Sciences Research.
Recent Research Publications:
Dubyk MD, Card RT, Whiting SJ, Boyle CAJ, Zlotkin SH, Paterson PG. Iron deficiency anemia prevalence at first stroke or transient ischemic attack. Canadian Journal of Neurological Sciences 39: 189-195, 2012.
Hackett MJ, Smith SE, Paterson PG, Nichol H, Pickering IJ and George GN. X-ray absorption spectroscopy at the sulfur K-edge: a new tool to investigate the biochemical mechanisms of neurodegeneration. ACS Chemical Neuroscience 3: 178-185, 2012.
Auriat AM, Silasi G, Wei Z, Paquette R, Paterson P, Nichol H, Colbourne F. Ferric iron chelation lowers brain iron levels after intracerebral hemorrhage in rats but does not improve outcome. Experimental Neurology 234:136–143, 2012.
Prosser-Loose EJ, Smith SE, Paterson PG. Experimental model considerations for the study of protein-energy malnutrition co-existing with ischemic brain injury. Current Neurovascular Research 8: 170-182, 2011.
Smith SE, Prosser-Loose EJ, Colbourne F, Paterson PG. Protein-energy malnutrition alters thermoregulatory homeostasis and the response to brain ischemia. Current Neurovascular Research 8:64-74, 2011.
Prosser-Loose, E.J., Verge, V.M.K., Cayabyab, F.S., and Paterson, P.G. Protein-energy malnutrition alters hippocampal plasticity-associated protein expression following global ischemia in the gerbil. Current Neurovascular Research 7: 341-360, 2010.
McEwen, B. R. and Paterson, P.G. Caloric restriction provided after global ischemia does not reduce hippocampal CA1 injury or improve functional recovery. Neuroscience 166: 263-270, 2010.
Research Category Key Words:
Nutrition, Stroke, Brain Ischemia, Protein-Energy Malnutrition, Caloric Restriction, Neuroplasticity