University of Saskatchewan

August 28, 2014   

Function Follows Form

Graham George, B.Sc., D.Phil.

Highlights

"There are very few techniques that can look at metals in situ. X-ray absorption spectroscopy is one. And it’s only the combination of these new detectors and high-intensity beamlines that have allowed us to do this work now."

Background

1983 Ph.D., University of Sussex, U.K.
1979 B.Sc. Kings College, London, U.K.

Published

More than 150 articles in refereed publications
Author of EXAFSPAK suite of data analysis programs

Mentored

3 graduate students
8 summer students
3 post-doctoral fellows
1 visiting scholar

Committees

Member, Advisory Board NIH Program Project “Mechanisms of Metal Ion Regulation in Human Cells”
Member, Canadian Light Source XAFS Beamline Team Management Committee
Member, American Chemical Society
Member, International XAFS Society, Standards and Criteria Committee and Data Analysis Programs and Procedures Subcommittee
Chairman, Stanford Synchrotron Radiation Laboratory Committee on Strategic Planning for Computing (1996-1999)
Member, Stanford University Rhodes – Marshall Panel (responsible for selection of Stanford University candidates for Rhodes Scholarships and Marshall Scholarships), (1997, 1999)
Member, Department of Energy Review Panel for the William R. Riley Environmental Molecular Sciences Laboratory, charged with evaluating laboratory operations (1998)

Consulting

Confidential consultant to a number of major corporations

Honours

  • Canada Research Chair in X-Ray Absorption Spectroscopy, Tier I
  • American Chemical Society (Division of Fuel Chemistry) Bituminous Coal Research Inc. R.A. Glenn Award

Other

Organized and chaired six international workshops

Contact Information

Graham George
Phone: (306) 966-5722
Email: graham.george@usask.ca

Dr. Graham George

Canada Research Chair in X-Ray Absorption Spectroscopy

It’s not only the dose that makes the poison; it’s the form. For instance, the metallic liquid mercury in thermometers is relatively benign. Dimethyl mercury, on the other hand, causes severe, permanent damage, especially to the nervous system.

“It’s not the metal that matters,” says Dr. Graham George. “There are plenty of mercury compounds that aren’t very poisonous and there are plenty of mercury compounds that are actually deadly.”

How mercury does its damage is little understood, and there are few treatment options available. Dr. George is using synchrotron-based x-ray absorption spectroscopy (XAFS) to study how mercury interacts chemically in the body and what forms it takes. This foundation knowledge is critical to designing molecules that can bind to the mercury and carry it out of the system. Such drugs, called chelators, already exist to treat mercury poisoning but they work relatively poorly, particularly against methyl mercury.

Solid knowledge of how mercury chemistry works could also have applications in cleaning up contaminated industrial sites, or even in water treatment plants to remove the metal from drinking water supplies.

“Our goals and our directions are to use the sychrotron to try to understand how mercury is processed biologically and to use that information to develop methods to remove it.”

Dr. George is also using x-ray absorption spectroscopy to explore the structure and function of sulphur in the body.

“We know it is very important but there isn’t much you can do with conventional analysis in terms of looking at the unperturbed living system,” he says.

Sulphur compounds regulate critical cell functions including apoptosis, or the process in which a cell is “switched off” and dies. When this process goes awry, cells don’t die when they are supposed to, leading to maladies like cancer. Conversely, the AIDS virus somehow activates the apoptosis trigger in the body’s defensive T-cells, causing them to commit suicide and to wreak havoc with the immune system. Clear understanding of sulphur chemistry in living systems opens the possibility of designing molecules to regulate cell functions and to treat these diseases.

About a third of Dr. George’s research program is devoted to metalloproteins. Metals form a vitally important part of about 30 per cent of the proteins in our bodies, and they are key to the function of some of the most important biochemisty such as how our bodies consume oxygen, a process that involves both iron and copper.

“Obtaining an in-depth understanding of the chemistry of metalloproteins, including the systems for metal transport and regulation, is one of the most challenging problems we face today.”

Dr. George explains his research is a foundation, the first step in the road to practical application. The mercury problem is an example of this.

“What we’re doing is trying to calculate, using quantum chemical methods, a drug to bind mercury – a custom chelator,” he says. “It’ll bind mercury but it won’t bind other things with anywhere near the same affinity. We’re a long way from actually achieving that.”