Philip Griebel

    Dr. Philip Griebel

    Professor

    Research areas


    • Developmental immunology
    • Comparative immunology
    • Mucosal immunology
    • Innate immunity
    • Vaccine delivery

    Current Research


    • Identify key genes regulating innate mucosal immune responses
    • Analyze the interaction between Mycobacterium avium subspecies paratuberculosis and the mucosal immune system.
    • Investigate the role of neutrophils in antigen presentation and dendritic cell maturation
    • Develop a vaccine to prevent TSE disease
    • Identify biomarkers of stress responses and mechanisms by which stress alters immune responses

    Recent Grants and Awards


    • Genome Canada. Pathogenomics of Innate Immunity. (Co-Applicant) (2005-2009).
    • NIH (Grand Challenges in Global Health- Bill and Melinda Gates Foundation). Linking Innate and Specific Immunity to Develop Single Dose Vaccines for Neonates. (2005-2010).
    • CCA. Pathogenomics and control of Mycobacterium avium subspecies paratuberculosis. (Co-Applicant) (2007-2010)
    • TSE Research Fund (U. of S). Immunoprophylaxis of bovine spongiform encephalopathy. (Co-Applicant) (2006-2009)
    • PrioNet. Immunoprophylaxis of bovine spongiform encephalopathy. (Co-Applicant) (2008-2010)
    • ALIDF. Pathogenomics and control of Mycobacterium avium subspecies paratuberculosis. (Co-Applicant) (2007-2010)
    • NSERC. Linking Innate and Adaptive Immunity: The Role of Neutrophils. (PI) (2008-2013)

    Current Courses


    • VTMC 832.3 – Infectious Disease Epidemiology
    • VACC 801.3 – A Multi-Disciplinary Introduction to Vaccinology and Immunotherapeutics
    • VTINT 580 – Strategic Vaccines Clinical Rotation

    Select Publications


    • Hodgson PD, Aich P, Manuja A, Hokamp K, Roche FM, Brinkman FSL, Potter A, Babiuk LA, and PJ Griebel. 2005. Effect of stress on viral-bacterial synergy in bovine respiratory disease: A review of potential mechanisms. Comp. Functional Genomics 6: 244-250.
    • Gaertner FH, Babiuk LA, Van Moorlehem EA, Beskorwayne TK, Lee SL, Shutter RW, Armstrong JM, and PJ Griebel. 2005. Amended Recombinant Cells (ARCsTM): An Efficient Production and Delivery Vehicle for Bovine IFN-?. J. Controlled Release 107(2): 189-202.
    • Nichani Ak, Mena A, Kaushik RS, Mutwiri GK, Townsend HGG, Hecker R, Krieg AM, Babiuk LA, and PJ Griebel. 2006. Stimulation of innate immune responses by CpG oligodeoxynucleotide in newborn lambs can reduce bovine herpes virus-1 shedding. Oligonucleotides 16(1): 57-66
    • Whale T, Beskorwayne T, Babiuk LA, and PJ Griebel. 2006. Bovine polymorphonuclear cells passively acquire membranes and integral membrane proteins from apoptotic and necrotic cells. J. Leuk. Biology 79:1226-1233
    • Whale TA, Wilson HL, Tikoo SK, Babiuk LA, and PJ Griebel. 2006. Passively acquired membrane proteins alter the functional capacity of bovine polymorphonuclear cells. J. Leuk. Biology 80: 481-491.
    • Mookherjee N, Wilson HL, Doria S, Popowych Y, Falsafi R, Yu J, Li Y, Veatch S, Roche FM, Brown KL, Brinkman, FSL, Hokamp K, Potter A, Babiuk LA, Griebel PJ, Hancock REW. 2006. Bovine and human cathelicidin cationic host defence peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide. J. Leuk. Biology 80: 1568-74.
    • Tsang C, Babiuk S, van Drunen Littel-van den Hurk S, Babiuk LA, and PJ Griebel. 2007. A single DNA immunization in combination with electroporation prolongs the primary immune response and maintains immune memory for six months. Vaccine 25, 5485-94.
    • Kindrachuk J, Potter JE, Brownlie R, Ficzycz AD, Griebel PJ, Mookherjee N, Mutwiri GW, Babiuk LA, Napper S. 2007. Nucleic acids exert a sequence-independent cooperative effect on sequence-dependent activation of TLR9. J Biol. Chem. 282(19): 13944-13953.
    • Wilson HL, Kaushik RS, Begg AA, Jalal S, Conner W, Mirakhur K, Van den Hurk J, Hokamp K, Roche FM, Brinkman FSL, Potter A, Babiuk LA, Griebel PJ, and Aich P. 2007. Comparative functional genomic analysis of rotavirus and coronavirus infection in neonatal calves. J. gen Virol 88 (Pt10), 2749-61.
    • Tsang CH, Mirakhur, KK, Babiuk LA, and PJ Griebel. 2007. Oral DNA Immunization in the Second Trimester Fetal Lamb and Secondary Immune Responses in the Neonate. Vaccine 25, 8469-8479.
    • Gerdts V, van Drunen Littel-van den Hurk S, Griebel PJ, and LA Babiuk. 2007. Use of Animal Infectious Disease Research in the Development of Human Vaccines. Future Microbiology 2(6), 667-675.