University of Saskatchewan

 

Nazarali, Adil


Professor
College of Pharmacy and Nutrition
University of Saskatchewan, 110 Science Place
Saskatoon, Saskatchewan, Canada
S7N 5C9
Telephone: (306) 966-6334
Facsimile: (306) 966-6377
Email:adil.nazarali@usask.ca
Website:http://www.usask.ca/pharmacy-nutrition/researchprograms/lab_mol_cell_bio/nazarali.html


Academic Degrees

B.Sc. (Portsmouth), M.Sc. (London), Ph.D. (Alberta)

Current Teaching

PHAR 409.3  Pharmaceutical Biotechnology

PHAR 898.3  Special Topics Graduate Course in Cellular Developmental Biology

PHAR 898.3  Special Topics Graduate Course in Molecular Biology and Pharmaceutical Biotechnology

Current and Recent Research Projects

Molecular biomarkers of toxicity and teratogenecity; drug-induced cleft palate and the role of Hox genes in palatogenesis, in vivo and in whole organ cultures.

Role of Hox genes in myelinating cells and multiple sclerosis.

Cloning and characterization of downstream targets of Hox genes.

Eye development.

Publications

Wei Z, Gabriel GG, Rui L, Cao X, Pennington PR, Chlan-Fourney J, Nazarali AJ, Baker GB and Mousseau DD. Monoamine oxidase-A physically interacts with presenilin-1 (M146V) in the mouse cortex. J. Alzheimer's Disease (in press).

Ji S, Doucette JR and Nazarali AJ, 2011. Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation.  Journal of Molecular Cell Biology, 0: 1–9.

Nazarali AJ, 2011. Marshall Nirenberg 1927-2010. Cellular and Molecular Neurobiology 6:805-807.Nazarali AJ and Talman WT, 2011. Special Issue on A Tribute to Marshall Nirenberg. Introduction. Cellular and Molecular Neurobiology, 6:803.

Wang Y, Zhang Y, He J, Zhang H, Xiao L, Nazarali A, Zhang Z, Zhang D, Tan Q, Kong J and Li XM, 2011. Hyperforin promotes mitochondrial function and development of oligodendrocytes. Journal of Neurochemistry, doi: 10.1111/j.1471-4159.2011.07433.

Wang JM, Doucette JR and Nazarali AJ, 2011. Conditional Tet-regulated over-expression of Hoxa2 in CG4 cells increases their proliferation and delays their differentiation into oligodendrocyte-like cells expressing myelin basic protein, Cellular and Molecular Neurobiology, 6:875-886.

Elsabahy M, Nazarali AJ and Foldvari M, 2011. Non-viral nucleic acid delivery: key challenges and future directions Current Drug Delivery 8: 235-244.

Brown, GD and Nazarali, AJ, 2010. Matrix metalloproteinase-25 has a functional role in mouse secondary palate development and is a downstream target of TGF-b3. BMC Developmental Biology 10:93-101.

Doucette, JR, Jiao R and Nazarali AJ, 2010. Age-related and cuprizone-induced changes in myelin and transcription factor gene expression and in oligodendrocyte cell densities in the rostral corpus callosum of mice. Cellular and Molecular Neurobiology, 30:607-629.

Zhang B, Wang X and  Nazarali AJ, 2010. Ascorbic acid reverses valproic acid induced inhibition of Hoxa2 and maintains glutathione homeostasis in mouse embryos in culture. Cellular and Molecular Neurobiology, 30:137-148.

Smith TM, Wang X, Zhang B, Kulyk W and Nazarali AJ, 2009.  Hoxa2 plays a direct role in murine palate development. Developmental Dynamics, 238: 2364-2373.

Ji L, Nazarali AJ and Paterson PG, 2008.  Protein-Energy Malnutrition Increases Activation of Transcription Factor, Nuclear Factor Kappa B, in Gerbil Hippocampus Following Global Ischemia. Journal of Nutritional Biochemistry, 19: 770-777.
Nicolay DJ, Doucette JR and Nazarali AJ, 2007.  Transcriptional Control of Oligodendrogenesis, GLIA, 55: 1287-1299.

Booth J, Nicolay DJ, Doucette JR and Nazarali AJ, 2007.  Hoxd1 is Expressed by Oligodendroglial Cells and Binds to a Region of the Human Myelin Oligodendrocyte Glycoprotein Promoter In Vitro. Cellular and Molecular Neurobiology, 27: 641-650.

Nazarali AJ, Zhang B and Wang X, 2007.  Effect of Valproic Acid on Glutathione Homeostasis in Mouse Whole Embryo Cultures. Proceedings of SECOTOX, 1:61-66.

Wang X, Zhang W and Nazarali AJ, 2007.  Toxic Effects of Valproic Acid on Mouse Palatal Development In Vitro, Proceedings of SECOTOX, 1: 139-144.

Nicolay DJ, Doucette JR and Nazarali AJ, 2006.  Transcriptional Regulation of Neurogenesis in the Olfactory Epithelium, Cellular and Molecular Neurobiology, 26: 803-821.

Akin Z and Nazarali AJ, 2005.  Hox Genes and their Candidate Downstream Targets in the Developing Central Nervous System, Cellular and Molecular Neurobiology, 25: 697-741. 

Nicolay D, Doucette JR and Nazarali AJ, 2004.  Early stages of Oligodendrocyte Development in the Embryonic Murine Spinal Cord proceed normally in the absence of Hoxa2 GLIA: 48: 14-26.

Nicolay D, Doucette JR and Nazarali AJ, 2004.  Hoxb4 in Oligodendrogenesis, Cellular and Molecular Neurobiology, 24: 357-366.

Anderson PL, Doucette JR and Nazarali AJ, 2003. A Novel Method of Eliminating Non-neuronal Proliferating Cells from Cultures of Mouse Dorsal Root Ganglia, Cellular and Molecular Neurobiology, 23: 205-210.