University of Saskatchewan

 

Lehotay, Denis


Associate Professor
Department of Pathology, College of Medicine
Provincial Laboratory
3211 Albert Street
Regina, Saskatchewan, Canada
S4S 5W6
Telephone: (306) 787-7900
Facsimile: (306) 787-1525
Email:dlehotay@health.gov.sk.ca


Academic Degrees

B.Sc. (Concordia), M.Sc., Ph.D. (McGill)

Current Teaching

Biochemical mechanisms of anthracycline cardiotoxicity.

Role of free radicals and lipid peroxidation in the pathophysiology of disease.

Clinical toxicology and pharmacogenomics.

Alcohol toxicity and Fetal Alcohol Syndrome (FAS).

Current and Recent Research Projects

Lung inflammation induced by exposure to swine barn air.

Lung microvascular inflammation.

3-methylindole toxicity in cattle.

Publications

Sochaski, M.A., W.J. Bartfay, S.R. Thorpe, J.W. Baynes, E. Bartfay, D.C. Lehotay and P.P. Liu.  2002.  Free radical damage in a mouse model of chronic iron-overload.  Metabolism 51(5): 645-651.

Jakeman, A., T. Thompson, J. McHattie and D.C. Lehotay.  2001.  Sensitive method for nontransferrin-bound iron quantification by graphite furnace absorption spectrometry.  Clin. Biochem. 34: 43-47.

Bartfay, W.J., D. Hou, D.C. Lehotay, E. Bartfay, X.P. Luo and P.P. Liu.  2000.   The cardioprotective effects of selenium and morin hydrate in a murine model of chronic iron-overload.  J. Trace Elem. Exp. Med. 13: 285-297.

Luo, X.P., B. Reichetzer, J. Trines, L.N. Benson and D.C. Lehotay.  1999.  L-carnitine attenuates doxorubicin-induced lipid peroxidation in rats.  Free Radical Bio. Med. 26: 1158-1165.

Cole, D.E.C., D.C. Lehotay and J. Evrovski.  1998.  Simplified simultaneous assay of total plasma homocysteine and methionine by HPLC and pulsed integrated amperometry.  Clin. Chem. 44: 188-190.

Toyokuni, S., X.P. Luo, T. Tanaka, K. Uchida, H. Hiai and D.C. Lehotay.  1997.  Induction of a wide range of C2-C12 aldehydes and C7-C12 acyloins in the kidney of Wistar rats after treatment with a renal carcinogen, ferric nitriloacetate.  Free Radical Bio. Med. 22: 1019-1027.