University of Saskatchewan

 

Hiebert, Linda


Professor
Department of Veterinary Biomedical Sciences
52 Campus Drive
Saskatoon, Saskatchewan, Canada
S7N 5B4
Telephone: (306) 966-7358
Facsimile: (306) 966-7376
Email:linda.hiebert@usask.ca


Academic Degrees

B.A., M.Sc., Ph.D. (Saskatchewan)

Current Teaching

TOX 836.5 General Toxicology I (Toxicokinetics section of team taught course)

TOX 837.5 General Toxicology II (Cardiovascular Toxicology section of team taught course)

VBMS 221.8 Physiology I (Course Coordinator, Cardiovascular section of team taught course)

VBMS 834.6 Physiology I (Cardiovascular section of team taught course)

VBMS 324.3 Animal Physiology I (Haematology, Cardiovascular section of team taught course)

BIOL 217.3 Introductory Animal Physiology (Neurophysiology and Special Senses section of team taught course)

Current and Recent Research Projects

Toxic effects of polonium-210 alpha radiation on human and animal systems using models of bovine, porcine and human endothelial cells, and bovine pulmonary epithelial cells.

Endothelial dysfunction in hypertension and diabetes.

Endothelial dysfunction associated with free radical injury.

βFGF activity and heparan sulphate depletion associated with diabetic microvascular complications.

The role of heparanase.

Studies in endothelial cell cultures and in a rat model of hyperglycemia.

Pharmacodynamic and pharmacokinetic studies of oral heparins and related glycosaminoglycans.

Publications

Thomas, P., B. Tracy, T. Ping, M.. Wickstrom, N. Sidhu and L. Hiebert.  2003.  Relative biological effectiveness (RBE) of polonium-210 alpha-particles vs. X-rays on lethality in bovine endothelial cells.  Int. J. Radiat. Biol. 79(2): 107-118.

Hiebert, L.M.  2002.  Oral heparins.  Clin. Lab. 48: 111-116.

Hiebert, L.M., S.M. Wice, T. Ping, R.E. Hileman, T. Polat and R.J. Linhardt.  2002.  Tissue distribution of [14C] sucrose octasulfate following oral administration to rats.  Pharmaceut. Res. 19(6): 838-844.

Ram, J.I. and L.M. Hiebert.  2001.  Marked variation in free radical injury between bovine and porcine endothelial cells cultured in different medium.  In Vitro Mol. Toxicol. 14(3): 209-217.

Hiebert, L.M., S.M. Wice, T. Ping, D. Herr and V. Laux.  2001.  Antithrombotic efficacy of the low molecular weight heparin, reviparin sodium, administered by the oral route.  Thromb. Haemostasis 85: 114-118.