Weber, Lynn Associate Professor Department of Veterinary Biomedical Sciences WCVM 1319, 51 Campus Drive Saskatoon, Saskatchewan, Canada S7N 5B4 Telephone: (306) 966-8734 Facsimile: (306) 966-7376 Email:lynn.weber@usask.ca

Academic Degrees

• BSc, Pharmacy, University of British Columbia
• PhD, Pharmacology & Toxicology, University of British Columbia
• Post-doctoral Fellow, Smooth Muscle Research Group, University of Calgary
• Post-doctoral Researcher, Zoology, Oklahoma State University

Current Teaching

Dr. Weber's main teaching responsibility is VBMS 221 (Physiology I) which is the core physiology course for veterinary students. The course includes sections of cardiovascular, renal and acid-base physiology. She also teaches in VBMS 323 (basic principles of pharmacology), covering sections on autonomic, cardiac and diuretic pharmacology. Finally, she contributes to graduate level teaching in cardiovascular physiology and environmental toxicology.

Current and Recent Research Projects

Dr. Weber's main research focus is on the effect of environmental toxicants on the cardiovascular system. In particular, she is interested in the interaction of toxicants with genes via nuclear receptors to produce alterations in development and function of the cardiovascular system in mammals and fish. These are her current research projects:

• Role of polycyclic aromatic hydrocarbons (PAHs) in tobacco smoke-induced vascular dysfunction.
• Dog epidemiology studies examining the effects of glycemic index, obesity and second-hand tobacco smoke on cardiovascular function.
• Interaction of genes and the environment with the aryl hydrocarbon receptor and fish cardiovascular function.
• Effects of metal mining effluents on fish larval development and performance.

Publications

Gentner, N.J., Weber, L.P. (2012) Environmental tobacco smoke, arterial stiffness and altered circadian blood pressure patterns are associated with lung inflammation and oxidative stress.  American Journal of Physiology 302, H818-H825.

Marit, J.S., Weber, L.P. (2012) Persistent effects on adult swim performance and energetics in zebrafish developmentally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Aquatic Toxicology 106-107, 131-139.

Goertzen, M.M.,  Hauck, D.W., Phibbs, J., Weber, L.P., Janz, D.M. (2012) Swim performance and energy homeostasis in spottail shiner (Notropis hudsonius) collected downstream of a uranium mill. Ecotoxicology & Environmental Safety 75, 142-150.

Gentner, N.J. and Weber, L.P. (2011) Intranasal benzo[a]pyrene alters circadian blood pressure patterns and causes lung inflammation in rats. Archives of Toxicology 85, 337-346.

Weber, L.P., Al-Dissi, A.N., Marit, J.S., German, T.N., Terletski, S.D. (2011) Role of carbon monoxide in impaired endothelial function mediated by acute second-hand tobacco, incense, and candle smoke exposures. Environmental Toxicology & Pharmacology 31, 453-459.

Anthony, J.M.G., Weber, L.P.,  Alkemade, S. (2011) Blood glucose and liver function in dogs administered a xylitol drinking water additive at zero, one and five times the dosage rates. Veterinary Science Development  1, 7-9.

Marit, J.S., Weber, L.P. (2011) Acute exposure to 2,4-dinitrophenol alters zebrafish swim performance and whole body triglyceride levels. Comparative Biochemistry and Physiology Part C 154, 14-18.

Al-Dissi, A.N. and Weber, L.P. (2011) Resveratrol preserves cardiac function, but does not prevent endothelial dysfunction or pulmonary inflammation after environmental tobacco smoke exposure. Food and Chemical Toxicology 49, 1584-1591.

Goertzen, M.M.,  Driessnack, M.K., Janz, D.M., Weber, L.P. (2011) Swimming performance and energy homeostasis in juvenile laboratory raised fathead minnow (Pimephales promelas) exposed to uranium mill effluent. Comparative Biochemistry and Physiology – Part C. 154, 420-426.