Stroke, a reduction in blood flow to a region of the brain, is a major cause of death and disability in North America. We are studying the potential for pre- and post- ischemic nutritional status (e.g. protein-energy malnutrition) to influence the extent of disability following stroke and the mechanisms by which such effects can be exerted. The effects of nutrients on antioxidant defense during the acute period following stroke and the neuroplastic events of the subsequent recovery period are studied.
Dubyk MD, Card RT, Whiting SJ, Boyle CAJ, Zlotkin SH, Paterson PG. Iron deficiency anemia prevalence at first stroke or transient ischemic attack. Canadian Journal of Neurological Sciences 39: 189-195, 2012.
Auriat AM, Silasi G, Wei Z, Paquette R, Paterson PG, Nichol H, Colbourne F. Ferric iron chelation lowers brain iron levels after intracerebral hemorrhage in rats but does not improve outcome. Experimental Neurology 234: 136-143, 2012.
Smith SE, Prosser-Loose EJ, Colbourne F, Paterson PG Protein-energy malnutrition alters thermoregulatory homeostasis and the response to brain ischemia.
Current Neurovascular Research. 2011 Jan 5. [Epub ahead of print]
Prosser-Loose, E.J., Verge, V.M.K., Cayabyab, F.S., and Paterson, P.G. Protein-energy malnutrition alters hippocampal plasticity-associated protein expression following global ischemia in the gerbil. Current Neurovascular Research 7:341-60, 2010.
McEwen, B. R. and Paterson, P.G. Caloric restriction provided after global ischemia does not reduce hippocampal CA1 injury or improve functional recovery. Neuroscience 166: 263-270, 2010.
Ji, J., Nazarali, A.J., and Paterson, P.G. Protein-energy malnutrition increases activation of the transcription factor, nuclear factor kappa B, in the gerbil hippocampus following global ischemia. Journal of Nutritional Biochemistry 19: 770-777, 2008.
Prosser-Loose, E.J, Saucier, D.M., and Paterson, P.G. Can a reward-based behavioral test be used to investigate the effect of protein-energy malnutrition on hippocampal function? Nutritional Neuroscience 10: 145-150, 2007.
Prosser-Loose, E.J. and Paterson, P.G. The FOOD Trial Collaboration: Nutritional supplementation strategies and acute stroke outcome. Nutrition Reviews 64: 289-294, 2006.