Nazarali, Adil

Professor

Adil Nazarali

College of Pharmacy and Nutrition
University of Saskatchewan, 110 Science Place
Saskatoon, Saskatchewan, Canada
S7N 5C9

Phone: (306) 966-6334

Email: aj.nazarali@usask.ca


Academic Degrees

  • B.Sc. (Portsmouth), M.Sc. (London), Ph.D. (Alberta)

Current Teaching

  • PHAR 409.3  Pharmaceutical Biotechnology
  • PHAR 898.3  Special Topics Graduate Course in Cellular Developmental Biology
  • PHAR 898.3  Special Topics Graduate Course in Molecular Biology and Pharmaceutical Biotechnology

Current and Recent Research Projects

  • Molecular biomarkers of toxicity and teratogenecity; drug-induced cleft palate and the role of Hox genes in palatogenesis, in vivo and in whole organ cultures.
  • Role of Hox genes in myelinating cells and multiple sclerosis.
  • Cloning and characterization of downstream targets of Hox genes.
  • Eye development.

Publications

Wei Z, Gabriel GG, Rui L, Cao X, Pennington PR, Chlan-Fourney J, Nazarali AJ, Baker GB and Mousseau DD. Monoamine oxidase-A physically interacts with presenilin-1 (M146V) in the mouse cortex. J. Alzheimer's Disease (in press).

Ji S, Doucette JR and Nazarali AJ, 2011. Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation.  Journal of Molecular Cell Biology, 0: 1–9.

Nazarali AJ, 2011. Marshall Nirenberg 1927-2010. Cellular and Molecular Neurobiology 6:805-807.Nazarali AJ and Talman WT, 2011. Special Issue on A Tribute to Marshall Nirenberg. Introduction. Cellular and Molecular Neurobiology, 6:803.

Wang Y, Zhang Y, He J, Zhang H, Xiao L, Nazarali A, Zhang Z, Zhang D, Tan Q, Kong J and Li XM, 2011. Hyperforin promotes mitochondrial function and development of oligodendrocytes. Journal of Neurochemistry, doi: 10.1111/j.1471-4159.2011.07433.

Wang JM, Doucette JR and Nazarali AJ, 2011. Conditional Tet-regulated over-expression of Hoxa2 in CG4 cells increases their proliferation and delays their differentiation into oligodendrocyte-like cells expressing myelin basic protein, Cellular and Molecular Neurobiology, 6:875-886.

Elsabahy M, Nazarali AJ and Foldvari M, 2011. Non-viral nucleic acid delivery: key challenges and future directions Current Drug Delivery 8: 235-244.

Brown, GD and Nazarali, AJ, 2010. Matrix metalloproteinase-25 has a functional role in mouse secondary palate development and is a downstream target of TGF-b3. BMC Developmental Biology 10:93-101.

Doucette, JR, Jiao R and Nazarali AJ, 2010. Age-related and cuprizone-induced changes in myelin and transcription factor gene expression and in oligodendrocyte cell densities in the rostral corpus callosum of mice. Cellular and Molecular Neurobiology, 30:607-629.

Zhang B, Wang X and  Nazarali AJ, 2010. Ascorbic acid reverses valproic acid induced inhibition of Hoxa2 and maintains glutathione homeostasis in mouse embryos in culture. Cellular and Molecular Neurobiology, 30:137-148.

Smith TM, Wang X, Zhang B, Kulyk W and Nazarali AJ, 2009.  Hoxa2 plays a direct role in murine palate development. Developmental Dynamics, 238: 2364-2373.

Ji L, Nazarali AJ and Paterson PG, 2008.  Protein-Energy Malnutrition Increases Activation of Transcription Factor, Nuclear Factor Kappa B, in Gerbil Hippocampus Following Global Ischemia. Journal of Nutritional Biochemistry, 19: 770-777.
Nicolay DJ, Doucette JR and Nazarali AJ, 2007.  Transcriptional Control of Oligodendrogenesis, GLIA, 55: 1287-1299.

Booth J, Nicolay DJ, Doucette JR and Nazarali AJ, 2007.  Hoxd1 is Expressed by Oligodendroglial Cells and Binds to a Region of the Human Myelin Oligodendrocyte Glycoprotein Promoter In Vitro. Cellular and Molecular Neurobiology, 27: 641-650.

Nazarali AJ, Zhang B and Wang X, 2007.  Effect of Valproic Acid on Glutathione Homeostasis in Mouse Whole Embryo Cultures. Proceedings of SECOTOX, 1:61-66.

Wang X, Zhang W and Nazarali AJ, 2007.  Toxic Effects of Valproic Acid on Mouse Palatal Development In Vitro, Proceedings of SECOTOX, 1: 139-144.

Nicolay DJ, Doucette JR and Nazarali AJ, 2006.  Transcriptional Regulation of Neurogenesis in the Olfactory Epithelium, Cellular and Molecular Neurobiology, 26: 803-821.

Akin Z and Nazarali AJ, 2005.  Hox Genes and their Candidate Downstream Targets in the Developing Central Nervous System, Cellular and Molecular Neurobiology, 25: 697-741. 

Nicolay D, Doucette JR and Nazarali AJ, 2004.  Early stages of Oligodendrocyte Development in the Embryonic Murine Spinal Cord proceed normally in the absence of Hoxa2 GLIA: 48: 14-26.

Nicolay D, Doucette JR and Nazarali AJ, 2004.  Hoxb4 in Oligodendrogenesis, Cellular and Molecular Neurobiology, 24: 357-366.

Anderson PL, Doucette JR and Nazarali AJ, 2003. A Novel Method of Eliminating Non-neuronal Proliferating Cells from Cultures of Mouse Dorsal Root Ganglia, Cellular and Molecular Neurobiology, 23: 205-210.