George, Graham

Professor

Graham George

Department of Geological Sciences
114 Science Place
Saskatoon, Saskatchewan, Canada
S7N 4R5

Phone: (306) 966-5722

Email: g.george@usask.ca

Website: http://homepage.usask.ca/~grg033/


Academic Degrees

  • B.Sc. (London, UK), D.Phil. (Sussex, UK)

Current Teaching

  • GEOL 451: Synchrotron Hard X-ray Absorption Spectroscopy
  • GEOL 851: Advanced Hard X-ray Absorption Spectroscopy

Current and Recent Research Projects

Metalloprotein structure and function: 

  • X-ray absorption spectroscopy and computational chemistry as a probe of detailed chemical structure and mechanisms of metalloprotein active sites.
  •             Spectroscopic and Computational Studies of Molybdenum and Tungsten Enzymes
  •             Copper in Health and Disease 

X-ray Absorption Spectroscopy and Computational Chemistry of Toxic Heavy Elements:

  •            X-ray absorption Spectroscopy as an in-situ probe of chemical form in organisms.
  •            A quantum chemical approach to novel metal and metalloid chelator drugs.
  •            Quantitative X-ray spectroscopic imaging of metals and metalloids in biological systems.
  •            Synergistic and antagonistic relationships in the toxicology of metals and metalloids.
  •           The Molecular Basis for Mercury Toxicity

Sulfur K-edge X-ray absorption spectroscopy as a probe of sulfur biochemistry in intact tissues.



Publications

Foust, R. D. Jr., A-M. Bauer, Constanza-Robinson, M., Blinn, D. W., Prince, R. C., Pickering, I. J., George, G. N. (2015) “Arsenic transfer and biotransformation in a fully characterized freshwater food web” Coord. Chem. Rev. 306(2), 558-565.

Hackett, M. J., Smith, S. E., Caine, S., Nichol, H., George, G. N., Pickering, I. J., Paterson, P. G. (2015) “Novel bio-spectroscopic imaging reveals disturbed protein homeostasis and thiol redox with protein aggregation prior to hippocampal CA1 pyramidal neuron death induced by global brain ischemia in the rat Free Rad. Biol. Med.89, 806-818.

Baldwin, G. S., George, G. N., Pushie, M. J. (2015) “High affinity binding of indium and ruthenium ions by gastrins” PLoS One.10(10), e0140126.

Fleming, D. E. B., Groves, J. W., Gherase, M. R., George, G. N., Pickering, I. J., Ponomarenko, O., Langan, G., Spallhloz, J. E., Alauddin, M., Ahsan, H., Ahmed, S., La Porte, P. F. (2015) “Soft tissue measurement of arsenic and selenium in an animal model using portable X-ray fluorescence” Radiat. Phys. Chem.116, 241-247.

MacDonald, T. C., Korbas, M., James, A. K., Sylvain, N. J., Hackett, M. J., Nehzati, S., Krone, P. H., George G. N., Pickering, I. J. (2015) “Interaction of mercury and selenium in the larval stage zebrafish vertebrate model”  Metallomics7, 1247-1255.

MacDonald, T., C., Nehzati, S.; Sylvain, N. J., James, A. K., Korbas, M., Caine, S., Pickering, I. J., George, G. N., Krone, P. H. (2015) “Phenylthiourea alters toxicity of mercury compounds in zebrafish larvae”  J. Inorg. Biochem. 151, 10-17.

Weinert, T., Huwiler, S. G., Kung, J. W., Weidenweber, S., Hellwig, P., Cotelesage, J. J. H., George, G. N., Ermler, U., Boll, M. (2015)  “Structural basis of the biological Birch reduction of the benzene ring”  Nature Chem. Biol., 11(8), 586-591.

Doonan, C. J., Gourlay, C., Nielsen, D., Ng, V., Smith, P., Evans, D., George, G. N., White, J., Young, C. G. (2015)  “d1 oxosulfido-Mo(V) compounds: First isolation and unambiguous characterization of an extended series”  Inorg. Chem. 54(13), 6386-6396.

Swanston, T. M., Varney, T., Coulthard, I., George, G. N., Pickering, I. J., Murphy, R., Cooper, D. (2015) “Synchrotron X-ray fluorescence imaging evidence of biogenic mercury identified in a burial in colonial Antigua”  J. Archaeol. Sci58, 26-30.

Choudhury, S., Hormes, J., Agyeman-Budu, D. N., Woll, A. R., George, G. N., Coulthard, I., Pickering, I. J. (2015) “Application of a spoked channel array to confocal X-ray fluorescence imaging and X-ray absorption spectroscopy of medieval stained glass” J. Anal. At. Spectrom30, 759-766.

Choudhury, S., Thomas, J. K., Sylvain, N. J., Ponomarenko, O., Gordon, R. A., Heald, S. M., Janz, D. M., Krone, P. H., Coulthard, I., George, G. N., Pickering, I. J., (2015) “Selenium preferentially accumulates in the eye lens following embryonic exposure: a confocal X-ray fluorescence imaging study” Environ. Sci. Technol49(4), 2255-2261.

Hackett, M. J., Britz, C. J., Paterson, P. G., Nichol, H., Pickering, I. J., George, G. N. (2015) “In situ bio-spectroscopic investigation of rapid ischemic and post-mortem induced biochemical alterations in the rat brain” ACS Chem. Neurosci. 6(2), 225-238.