George, Graham

Professor

Graham George

Department of Geological Sciences
114 Science Place
Saskatoon, Saskatchewan, Canada
S7N 4R5

Phone: (306) 966-5722

Email: g.george@usask.ca

Website: http://www.usask.ca/geology/nfaculty/gg/intro.htm


Academic Degrees

  • B.Sc. (London, UK), D.Phil. (Sussex, UK)

Current Teaching

  • GEOL 451: Synchrotron Hard X-ray Absorption Spectroscopy
  • GEOL 898: Advanced Hard X-ray Absorption Spectroscopy

Current and Recent Research Projects

Metalloprotein structure and function: 

X-ray absorption spectroscopy and computational chemistry as a probe of detailed chemical structure and mechanisms of metalloprotein active sites. 

  • Spectroscopic and Computational Studies of Molybdenum EnzymesX-ray Absorption Spectroscopy and Computational Chemistry of Toxic Heavy Elements:
  • X-ray absorption Spectroscopy as an in-situ probe of chemical form in organisms.
  • A quantum chemical approach to novel metal and metalloid chelator drugs.
  • Quantitative X-ray spectroscopic imaging of metals and metalloids in biological systems.
  • Synergistic and antagonistic relationships in the toxicology of metals and metalloids.
  • The Molecular Basis for Mercury Toxicity
  • Copper in Health and Disease
  • Sulfur K-edge X-ray absorption spectroscopy as a probe of sulfur biochemistry in intact tissues.

Publications

Zhang, L., Lichtmannegger, J., Summer, K. H., Webb, S., Pickering, I. J., George, G. N. (2009) "Tracing Copper-Thiomolybdate Complexes in a Prospective Treatment for Wilson's Disease" Biochemistry (in the press).

Rivas, M. G., Carepo, M. S., Mota, C. S., Korbas, M., Durand, M.-C., Lopes, A.T., Brondino, C.D., Pereira, A.S., George, G.N., Dolla, A.. Moura, J.J.G, Moura, I. (2009) "Molybdenum induces the expression of a protein containing a new heterometallic Mo-Fe cluster in Desulfovibrio alaskensisBiochemistry (in the press).

George, G. N., Prince, R. C., Singh, S. P., Pickering, I. J. (2009) "Arsenic K-edge X-ray Absorption Spectroscopy of Arsenic in Seafood"Molecular Nutrition and Food Research (in the press).

Popescu, B.F.G., George, M.J., Bergmann, U., Garachtchenko, A.V., Kelly, M.E., McCrea, R.P.E., Lüning, K., Devon, R. M., George, G. N., Hanson, A. D., Harder, S. M., Chapman, L. D., Pickering, I. J., Nichol, H. (2009) "Mapping metals in Parkinson's and normal brain using rapid-scanning X-ray fluorescence" Phys. Med. Biol. 54, 651-663.

Dias, A.V., Mulvihill, C.M., Leach, M.R., Pickering, I.J., George, G.N., Zamble, D.B. (2008) "Structural and Biological Analysis of the Metal Sites of Escherichia coli Hydrogenase Accessory Protein HypB" Biochemistry 47(46), 11981-11991.