College of Pharmacy and Nutrition
3D01.8 Health Sciences
- Ph.D. (Pharmaceutical Sciences), University of Kentucky, Lexington, KY, USA (2002)
- MSc. (Vet. Physiological Sciences), University of Saskatchewan, Saskatoon, Canada (1997)
- DVM. Western College of Veterinary Medicine, Saskatoon, SK (1994)
- BSc. (Biology), University of Saskatchewan, Saskatoon, Canada (1989)
Dr. Alcorn’s research interests encompass two principal areas. The first area involves investigations into the determinants of neonatal exposure risk when breastfeeding mothers require medications. Her laboratory focuses on the developmental maturation of drug elimination mechanisms and the elaboration of predictive models of drug elimination for a priori assessments of drug elimination capacity in the neonate. Research in the laboratory has moved towards investigations into drug-nutrient transporter interactions in the nursing mother-neonate dyad and the consequent outcomes of such interactions on breast milk nutrient composition and biochemical/ physiological development of the nursing neonate. Dr. Alcorn’s second principal area of research involves investigations into the health benefits of flaxseed lignans and their underlying mechanism(s) of action. Specifically, this laboratory evaluates lignan pharmacokinetics and conducts investigations into the pharmacological mechanisms through which lignans affect cholesterol and glucose homeostasis. Dr. Alcorn’s research utilizes a variety of pharmaceutical analysis, molecular biology and biochemical methods as well as cell culture systems and animal models in attempts to generate new understandings in these areas of investigation.
Mukker, J.K., Singh, R.S.P., Muir, A.D., Krol, E.S., Alcorn, J. Comparative pharmacokinetics of purified flaxseed and associated mammalian lignans in male Wistar rats(2015) British Journal of Nutrition, 113 (5), pp. 749-757.
Singh, R.S.P., Michel, D., Das, U., Dimmock, J.R., Alcorn, J. Cytotoxic 1,5-diaryl-3-oxo-1,5-pentadienes: An assessment and comparison of membrane permeability using Caco-2 and MDCK monolayers(2014) Bioorganic and Medicinal Chemistry Letters, 24 (22), pp. 5199-5202.
Sampieri, F., Alcorn, J., Allen, A.L., Clark, C.R., Vannucci, F.A., Pusterla, N., Mapes, S., Ball, K.R., Dowling, P.M., Thompson, J., Bernstein, L.R., Gebhart, C.J., Hamilton, D.L.Pharmacokinetics of gallium maltolate in Lawsonia intracellularis-infected and uninfected rabbits(2014) Journal of veterinary pharmacology and therapeutics, 37 (5), pp. 486-499.
Sampieri, F., Alcorn, J., Allen, A.L., Clark, C.R., Vannucci, F.A., Pusterla, N., Mapes, S., Ball, K.R., Dowling, P.M., Thompson, J., Bernstein, L.R., Gebhart, C.J., Hamilton, D.L.Pharmacokinetics of gallium maltolate in lawsoniaintracellularis-infected and uninfected rabbits(2014) Journal of Veterinary Pharmacology and Therapeutics,. Article in Press.
Mukker, J.K., Michel, D., Muir, A.D., Krol, E.S., Alcorn, J. Permeability and conjugative metabolism of flaxseed lignans by caco-2 human intestinal cells(2014) Journal of Natural Products, 77 (1), pp. 29-34.
Sampieri, F., Allen, A.L., Alcorn, J., Clark, C.R., Vannucci, F.A., Pusterla, N., Mapes, S.M., Ball, K.R., Dowling, P.M., Thompson, J., Bernstein, L.R., Gebhart, C.J., Hamilton, D.L.Efficacy of gallium maltolate against Lawsonia intracellularis infection in a rabbit model(2014) Journal of Veterinary Pharmacology and Therapeutics, 37 (6), pp. 571-578.
Ambros, B., Alcorn, J., Duke-Novakovski, T., Livingston, A., Dowling, P.M. Pharmacokinetics and pharmacodynamics of a constant rate infusion of fentanyl (5 μg/kg/h) in awake cats(2014) American Journal of Veterinary Research, 75 (8), pp. 716-721.
Das, U., Singh, R.S.P., Alcorn, J., Hickman, M.R., Sciotti, R.J., Leed, S.E., Lee, P.J., Roncal, N., Dimmock, J.R.3,5-Bis(benzylidene)-4-piperidones and related N-acyl analogs: A novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum(2013) Bioorganic and Medicinal Chemistry, 21 (23), pp. 7250-7256.
Berry, M.D., Shitut, M.R., Almousa, A., Alcorn, J., Tomberli, B. Membrane permeability of trace amines: Evidence for a regulated, activity-dependent, nonexocytotic, synaptic release(2013) Synapse, 67 (10), pp. 656-667.
Sultan, A., Ling, B., Zhang, H., Ma, B., Michel, D., Alcorn, J., Yang, J. Synergistic effect between sphingosine-1-phosphate and chemotherapy drugs against human brainmetastasized breast cancer MDA-MB-361 cells(2013) Journal of Cancer, 4 (4), pp. 315-319. Link
Billinsky J, Glew RA, Cornish SM, Chilibeck PD, Whiting SJ, Thorpe LU, Alcorn J, Paus-Jenssen L, Hadjistavropoulos T. (2013). No Evidence of Adverse Effect on Blood Glucoseor Blood Pressure in Middle Aged or Older Adults Following 6 Months of Flax LignanSupplementation in a Randomized Controlled Trial. Pharmaceutical Biology
Singh RS, Das U, Auschwitz JM, Leed SE, Hickman MR, Dimmock JR, Alcorn J. (2013). From a cytotoxic agent to the discovery of a novel antimalarial agent. Bioorganic & medicinal chemistry letters 23(2).
Sultan A, Ling BB, Zhang H, Ma B, Michel D, Alcorn J, Yang J. (2013) Synergistic effect between sphingosine-1-phosphate and chemotherapy drugs agains human brainmetastasized breast cancer MDA-MB-361 cells. J Cancer 4(4):315-319.
Izadifar M, Alcorn J. (2013) Mass transfer modeling of hepatic drug elimination using local volume averaging approach. Frontiers in Heat and Mass Transfer DOI: 10.5098/hmt.v3.3.3005
Billinsky J, Maloney K, Krol E, Alcorn J (2012). A comparison between lignans from creosote bush and flaxseed and their potential to inhibit cytochrome P450 enzyme activity. Drug Discovery Research in Pharmacognosy, Omboon Vallisuta and Suleiman M. Olimat (Ed.), ISBN: 978-953-51-0213-7.
Viveky N, Toffelmire L, Thorpe L, Billinsky J, Alcorn J, Hadjistavropoulos T, Whiting SJ. (2012). Use of vitamin and mineral supplements in long-term care home residents. Applied physiology, nutrition, and metabolism 37(1).
Abeysekara S, Zello GA, Lohmann KL, Alcorn J, Hamilton DL, Naylor JM. (2012). Infusion of sodium bicarbonate in experimentally induced metabolic acidosis does not provoke cerebrospinal fluid (CSF) acidosis in calves. Canadian journal of veterinary research 76(1).
Ling B, Peng F, Alcorn J , Lohmann K, Bandy B, Zello GA. (2012). D-Lactate altered mitochondrial energy production in rat brain and heart but not liver. Nutrition & Metabolism 9(1).
Chen J, Woodbury MR, Alcorn J, Honaramooz A. (2012). Dietary supplementation of female rats with elk velvet antler improves physical and neurological development of offspring. Evidence-based complementary and alternative medicine : eCAM
Ling B, Aziz C, Alcorn J. (2012). Systematic Evaluation of Key L- Carnitine Homeostasis Mechanisms during Postnatal Development in Rat. Nutrition and Metabolism 9(1).
Ling B, Chen L, Alcorn J, Ma B, Yang J. (2011). Sphingosine-1- phosphate: a potential therapeutic agent against human breast cancer. Investigational New Drugs 29(2).
Izadifar M, Baik OD, Alcorn J. (2011). Mechanistic modeling of drug elimination by the liver using local volume averaging method. Annual International Conference of the IEEE Engineering in Medicine and Biology Society.
Eichhorst J , Alcorn J, Lepage J , Etter M , Antonishyn NA , Fitterer B , Birch DA , Agopsowicz KL , Ruthnum L , Greenberg CR , Lehotay DC. (2010). Elevated neonatal 3- OH isovalerylcarnitine due to breast milk sources in maternal 3-MCC deficiency. Molecular Genetics and Metabolism. 101(1).
Chen L, Ling BB, Alcorn J, Yang J. (2009) Analysis of the Expression of Human N-myristoyltransferase 1 (hNMT-1) in Cancers (Open Biomarkers Journal 2:6-10)
Elbarbry FA, Alcorn J (2009) Ontogeny of glutathione and glutathione-related antioxidant enzymes in rat liver (Research in Veterinary Science 87(2):242-2.
Ling B, Alcorn J, Laarveld B, Olkowski AA (2009). Toxin metabolism potential in Richardson ground squirrels (Spermophilus richardsonii) in the context of chemical control of this pest. Journal of Pest Science 82(3):273-291.
Felmlee MA, Woo, G. Simko E, Krol ES, Muir AD, Alcorn J. (2009) Effects of the flaxseed lignans secoisolariciresinol diglucoside and its aglycone on serum and hepatic lipids in hyperlipidemic rats. British Journal of Nutrition 102(3):361-9.
Nain, S, Ling, BB, Bandy, B, Alcorn, J, Wojnarowicz, CM, Laarveld, B, Olkowski, AA. (2008). The Role of Oxidative Stress in the Development of Congestive Heart Failure in a Chicken Genotype Selected for Rapid Growth. Avian Pathology 37(4):367-73.
Olkowski AA, Wojnarowicz CM, Nain S, Ling BB, Alcorn J, Laarveld B. (2008) A Study on Pathogenesis of Sudden Death Syndrome in Broiler Chickens. Research in Veterinary Science 85:131-140.
Sokoro A, Zhang Z, Eichhorst JC, Zello G, House JD, Alcorn J, Lehotay DC. (2008) Formate pharmacokinetics during formate administration in folate-deficient young swine. Metabolism: Clinical and Experimental 57:920-926.
Ling BB and Alcorn J (2008) Acute administration of Cefepime lowers L-carnitine concentrations in early lactation stage rat milk. Journal of Nutrition 138:1317-1322.
Alcorn, J and McNamara PJ (2008). Using ontogeny information to build predictive models for drug elimination. Drug Discovery Today 13(11-12):507-512.
Nain, S, Ling, B., Alcorn, J., Wojnarowicz, C., Laarveld, B., Olkowski, A.A. (2008) Biochemical Factors Limiting Myocardial Energy in a Chicken Genotype Selected for Rapid Growth Comparative Biochemistry and Physiology, Part A 149: 36–43.