Giesy, John

Professor & Canada Research Chair in Environmental Toxicology

John Giesy

Department of Veterinary Biomedical Sciences
Toxicology Centre
44 Campus Drive
Saskatoon, SK
S7N 5B3

Phone: (306) 966-2096



Academic Degrees

  • B.Sc. (Alma College), M.Sc., Ph.D. (Michigan State)

Current and Recent Research Projects

  • Toxicity and reproductive effects of herbicides, chlorinated dioxins, and perfluorinated compounds in fish and fish-eating mammals.
  • Fate and effects of PAHs, pesticides, and halogenated and perflourinated compounds in the environment.
  • Effects of endocrine modulating compounds in fish and wildlife.
  • Development and application of analytical and bioanalytical techniques to environmental issues.
  • Ecological risk assessment of industrial and agricultural chemicals.


Professor Giesy has published 1,060 peer‑reviewed works and is a highly cited author and is among the top 0.001% of active authors in the world (ISI) and the most cited author in the world in the combined fields of Ecology and Environmental Sciences with an Hirsch (H) index of 102 with more than 43,921 citations.  His i10 Index (number of papers cited more than 10 times) is 612.  Some recent publications include:

Morandi, G.D., S. Wiseman, A.DS. Pereira, R. Mankidy, I.G. Gault, J.W. Martin and J.P. Giesy, 2015.  Effects-Directed Analysis of Dissolved Organic Compounds in Oil Sands Process Affected Water (OSPW). Environ. Sci. Technol. 49:12395-12404.

Al Naggar, Y., S. Wiseman, J.-X. Sun, G. C. Cutler, M. Aboul-Soud, E. Naiem, M. Mona, A. Seif, and J.P. Giesy. 2015. Effects of Environmentally-relevant Mixtures of Four Common Organophosphorus Insecticides on the Honey Bee (Apis mellifera L.). J. Insect Physiol. 82:85-91.

Zhu, Y.-R, F.-C. Wu, Z.-Q. He, J.P. Giesy, W.-Y. Feng, Y.-S. Mu, C.-L. Feng, X.-L. Zhao, H.-Q. Liao and Z. Tang. 2015. Influence of Natural Organic Matter on the Bioavailability and Preservation of Organic Phosphorus in Lake Sediments. Chem. Geol. 397:51–60.  

Xu, Y. S. Wei, Q.-D. Qin, M. H.-W. Lamb and J.P. Giesy. 2015. AhR-Mediated Activities and Compounds in Sediments of Meiliang Bay, Taihu Lake, China Determined by in vitro Bioassay and Instrumental Analysis. Royal Soc. Chem. Adv. 5:55746–55755.

Peng, H., C.-L. Chen, J. Cantina, D.M.V. Saunders, J.-X. Sun, S. Tang, G. Codling, M. Hecker, S. Wiseman, P.D. Jones, A. Li, K.J. Rockne, and J.P. Giesy. 2015. Untargeted Identification of Organo-Bromine Compounds in Lake Sediments by Ultrahigh-Resolution Mass Spectrometry with the Data-Independent Precursor Isolation and Characteristic Fragment Method. Anal. Chem. 87:10237-10246.

Chen Y, S.-Y. Yu, S. Tang, Y.-B. Li H.-L. Liu, X.-H. Zhang, G.-Y. Su, B. Li, H.-X.Yu and J.P. Giesy.  2016.  Site-specific Water Quality Criteria for Aquatic Ecosystems: A Case Study of Pentachlorophenol for Tai Lake, China. Sci. Tot. Environ. 541:65-73.

Codling, G., Y. Al Naggar, J.P. Giesy and A.J. Robertson.  2016.  Concentrations of Neonicotinoid insecticides in Honey, Pollen and Honey Bees (Apis mellifera L.) in Central Saskatchewan, Canada.  Chemosphere. 144: 2321-2328.

Guan, M, G. Su, J.P. Giesy and X. Zhang.  2016.  Classification and Toxicity Mechanisms of Novel Flame Retardants (NFRs) Based on Whole Genome Expression Profiling. Chemosphere. 144:2150-2157.

Shi W, D. Deng, Y. Wang, G. Hu, J. Guo, X. Zhang, X. Wang, J.P. Giesy, H. Yu and Z. Wang.  2015.  Causes of Endocrine Disrupting Potencies in Surface Water in East China. Chemosphere. 144:1435-1442.

Zhang, J, X. Zhang, P. Xia, R. Zhang, Y. Wu, J. Xia, G. Su, J. Zhang, J.P. Giesy, Z. Wang, D.L. Villeneuve and H. Yu.  2016.  Activation of AhR-Mediated Toxicity Pathway by Emerging Pollutants Polychlorinated Diphenyl Sulfides. Chemosphere. 144:1754-1762.

Ma, Z.-Y, Y.-J. Yu, S. Tang, H.-L. Liu, G.-Y. Su, Y.-W. Xie, Yuwei Xie and J.P. Giesy, M. Hecker and H.-X. Yu.  2015.  Effects of Tris (2-butoxyethyl) Phosphate (TBOEP) on Endocrine Axes During Development of Early Life Stages of Zebrafish (Danio rerio). Aquatic Toxicol. 169:196–203.

Li, H., G.-Y. Su, M. Zou, L.-Q. Yu, R.J. Letcher, H.-X Yu, J.P. Giesy, B.-S. Zhou and C.-S. Liu.  2015.  Effects of Tris(1,3-dichloro-2-propyl) Phosphate (TDCPP) on Growth, Reproduction and Gene Transcription of in Daphnia magna at Environmentally Relevant Concentrations.  Envir. Sci. Technol.  49:12975−12983.

Al Harbi, H.A., D.M.V. Saunders, A.-Mousab, J. Alcorna, A.S. Pereira; J.W. Martin, J.P. Giesy and S.B. Wiseman.  2016.  Inhibition of ABC Transport Proteins by Oil Sands Process Affected Water. Aquatic Toxicol. 170: 81–88.

Peng, H., C.-L. Chen, J. Cantin, D.M.V. Saunders, J.-X. Sun, S. Tang, G. Codling, M. Hecker, S. Wiseman, P.D. Jones, A. Li, K.J. Rockne, N.C. Sturchio and J.P. Giesy. 2015.  Untargeted Screening and Distribution of Organo-bromine Compounds in Sediments of Lake Michigan.  Environ. Sci. Technol.  50:321-330.

Zhu, Y. X.-F. Ma, G.-Y. Su, L.-Q. Yu, R.J. Letcher, J. Hou, H.-X. Yu, J.P. Giesy and C.-S. Liu. 2015.  Environmentally Relevant Concentrations of the Flame Retardant tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Inhibits Growth of Female Zebrafish and Decreases Fecundity.Environ. Sci. Technol.49:14479-14587.

Seston, R.M., J.P. Giesy, T.B. Fredricks, D.L. Tazelaar, S.J. Coefield, P.W. Bradley, S.A. Roark, J.L. Newsted, D.P. Kay and M.J. Zwiernik. 2012. Dietary- and Tissue-Based Exposure of Belted Kingfisher to PCDFs and PCDDs in the Tittabawassee River Floodplains, Midland, MI, USA. Environ. Toxicol. Chem. (In Press)

Hecker, M., J.S. Khim, J.P. Giesy, S.-Q. Li, and J.H. Ryu.  2012.  Seasonal Dynamics of Nutrient Loading and Chlorophyll A in a Northern Prairies Reservoir, Saskatchewan, Canada.  J. Wat. Resour. Protect.  4:180-202.  DOI: 10.4236/jwarp.2012.44021

Jin, X., J.P. Giesy. 2012.  A Tiered Ecological Risk Assessment of Three Chlorophenols in Chinese Surface Waters.  Environ. Sci. Polut Res.  DOI 10.1007/s11356-011-0660-8.  (In Press).

Zhang, K., Y. Wan, P.D. Jones, S. Wiseman, M.H.W. Lam, J.P. Giesy, and J. Hu.  2012.  Occurences and Fates of Hydroxylated Polybrominated Diphenyl Ethers in Marine Sediments in Relation to Trophodynamics.  Environ. Sci. Technol.  46:2148-2155.  DOI:  10.1021/es203195s

Jin, X., J. Zha, Y. Xu, J.P. Giesy, and J. Hu Wang.  Toxicity of Petachlorophenol to Native Species in the Yangtze River.  Environ. Sci. Polut Res. 19:609-618.  DOI:  10.1007/s.11356-011-0594-1

Luo, W., T. Wang, W. Jiao, W. Hu, J.E Naile, J.-S. Khim, J.P. Giesy and Y.-L. Lu.  2012.  Mercury in Coastal Watersheds Along the Northern Bohai and Yellow Seas, China.  J. Haz Mat. DOI:10.1016/j.hazmat.2012.02.052 (In Press)

Bo, J., J.P. Giesy, R. Ye, K.-J. Wang, J.S. Le and D.W.T. Au.  2012.  Identification of Differentially Expressed Genes and Quantitative Expression of Complement Genes in the Liver of Marine Medaka (Orizias melastigma) Challenged with Vibrio parahameboliticus.  Comp. Biochem. Physiol. Part D.  DOI:  10.1016/j.cbd.2012.02.005 (In Press)

Wang, T., J.-S. Khim, C. Chen, J.E. Naile, Y.-L. Lu, K. Kannan, J.-S. Park, and J.P. Giesy.  2012.  Perfluorinated Compounds in Surface Waters from Northern China: Comparison to Level of Industrialization. Environ. Internat. 42:37-46. DOI:  10.1016/j.envint.2011.03.023

Shi, W., F.X. Zhang, G.-J. Hu, Y.-Q. Hao, X.-W. Zhang, H.-L. Liu, S. Wei, J.P. Giesy and H.-X Yu.  2012.  Thyroid hormone disrupting activities associated with phthalate esters in water sources from Yangtze River Delta. Environ. Internat. 42:117-123.  DOI:10.1016/j.envint.2011.05.013

Doering, J.A., S. Wiseman, S.C. Beitel, B.J. Tendler, J.P. Giesy, and M. Hecker.  2012.  Tissue Specificity of Aryl Hydrocarbon Receptor (AhR)-Mediated Responses and Relative Sensitivity of White Sturgeon (Acipenser transmontanus) to to AhR Agonists.  Aquatic Toxicol. 114-115:125-133.  DOI:10.1016/j.aquatox.2012.02.015

Zhang, X., M. Hecker, P. D. Jones, J.L. Newsted, D. Au, D., R.Y. Kong, R.S.S. Wu, and J.P. Giesy. (2008). Responses of the Medaka HPG Axis PCR Array and Reproduction to Prochloraz and Ketoconazole.  Environ Sci Technol. 42:6762-6769.

 Zwiernik, M., D. Kay, J. Moore, K. J. Beckett, J. S. Khim, J.L. Newsted, S.A. Roark and J. P. Giesy.  2008.  Exposure and Effects Assessment of Resident Mink (Mustela vison) Exposed to Polychlorinated Dibenzofurans and other Dioxin-like Compounds in the Tittabawassee River Basin, Midland, Michigan, USA. Env. Toxicol. Chem.  27:2076-2087.

 Reagen, W.K., M.E. Ellefson, K Kannan and J. P. Giesy.  2008.  Comparison of extraction and quantification methods of perfluorinated compounds in human plasma, serum, and whole blood.  Analytica Chimica Acta 628:214-221.

 Solomon, K.R., J.A. Carr, L.H. Du Preez, J.P. Giesy, R. J. Kendall. E.E. Smith, G.J. Van Der Kraak.  2008.  Effects of Atrazine on Fish, Amphibians and Aquatic Reptiles:  A Critical Review.  Crit. Rev. Toxicol. 38:721-772.

 Novák, J., V. Jálová, J. P. Giesy and K. Hilscherová.  2009.  Pollutants in particulate and gaseous fractions of ambient air interfere with multiple signaling pathways in vitro.  Environ. Internat.  35:43-49.  doi:10.1016/j.envint.2008.06.006.

 Luo, W., Y.-L. Lu, B. Wang, X.-J. Tong, G. Wang, Y.-J. Shi, T. Wang and J.P. Giesy.  2008.  Distribution and Sources of Mercury in Soils from Former Industrialized Urban Areas of Beijing, China.  Environ Monit Assess. DOI 10.1007/s10661-008-0600-3.

 Yeung, L.W.Y., Y. Miyake, S. Taniyasu, Y. Wang, H. Yu, M.K. So, G.. Jiang, Y. Wu, J. Li, J.P. Giesy, N. Yamashita, and P.K.S. Lam.  2008.  Perfluorinated Compounds and Total and Extractable Organic Fluorine in Human Blood Samples from China  Environ. Sci. Technol. 42:8140-8145.

 Zhang, X., M. Hecker, J.-W. Park., A.R. Tompsett, P.D. Jones, J.L. Newsted, D.W.T. Au, R.T.C. Kong, R.S.S. Wu, and  J.P. Giesy.  (2007).  Time-dependent Tanscriptional Pofiles of Hpothalamic-Ptuitary-Gnadal (HPG) Ais in Mdaka (O. latipes) Exposed to to Fadrozole and 17beta-trenbolone. Environ Toxicol Chem. 27:2504-2511.