Weber, Lynn

Associate Professor

Lynn Weber

Department of Veterinary Biomedical Sciences
WCVM 1319, 51 Campus Drive
Saskatoon, Saskatchewan, Canada
S7N 5B4

Phone: 306-966-8734

Email: lynn.weber@usask.ca


Academic Degrees

  • BSc, Pharmacy, University of British Columbia
  • PhD, Pharmacology & Toxicology, University of British Columbia
  • Post-doctoral Fellow, Smooth Muscle Research Group, University of Calgary
  • Post-doctoral Researcher, Zoology, Oklahoma State University

Current Teaching

Dr. Weber's main teaching responsibility is VBMS 224 (Veterinary Physiology) which is the core physiology course for veterinary students. The course includes sections of basic cellular, neural, muscle and hematological physiology. She also teaches in VBMS 333 (General Pharmacology), covering sections on autonomic, cardiac and diuretic pharmacology. She teaches a core toxicology graduate course VBMS 855 (Integrative Cardiovascular Physiology & Toxicology) and contributes sections to several other graduate toxicology courses in cardiovascular physiology and environmental toxicology.


Current and Recent Research Projects

Dr. Weber's main research theme is on the effect of environmental influences on the cardiovascular system. In particular, she is interested in the interaction of toxicants, nutrition and climate change on cardiovascular and metabolic in mammals and fish.

These are her current research projects:

  • Interaction between polycyclic aromatic hydrocarbons (PAHs) and the aryl hydrocarbon receptor with cardiac and metabolic responses to thermal challenges in fish. 
  • Effects of metal mining effluents on fish larval development, metabolic health and performance.
  • Dog and cat nutrition studies examining the effects of glycemic index, obesity and the toxic glucose metabolite, methylglyoxal, on cardiovascular and metabolic health. 
  • Mechanisms of cardiometabolic effects of vitamin D deficiency and toxicity.

Publications

Morton, K.A., Hargreaves, L., Mortazavi, S., Weber, L.P., Blanco, A.M., Unniappan, S. 2018. Tissue specific expression and circulating concentrations of nesfatin-1 in domestic animals. Domestic Animal Endocrinology DOI.org/10.1016/j.domaniend.2018.04.006.

Panahifar, A., Chapman,  D., Weber, L.P., Samadi, N., Cooper, D.M. 2018. Biodistribution of strontium and barium in the developing and mature skeleton of rats. Journal of Bone and Mineral Metabolism DOI:10.1007/s00774-018-0936-x.

Pettem, C.M., Briens, J.M., Janz, D.M., Weber, L.P. 2018. Cardiometabolic response of juvenile rainbow trout to dietary selenomethionine. Aquatic Toxicology 198, 175-189. DOI.org/10.1016/j.aquatox.2018.02.022.

Pettem, C.M., Weber, L.P., Janz, D.M. 2017. Cardiac and metabolic effects of dietary selenomethionine exposure in adult zebrafish. Toxicological Sciences 159, 449-460.

Sundarrajan, L., Yeung, C., Hahn, L., Weber, L.P., Unniappan, S. 2017. Irisin Regulates cardiac physiology in zebrafish. Plos One 12, e0181461 DOI.org/10.1371/journal.pone.0181461.

Demuth, B., Ferrari, M., Weber, L.P., Janz, D., Chivers, D. 2017. Exposure to a contextually neutral stressor      potentiates fear conditioning in juvenile rainbow trout, Oncorhynchus mykiss. Hormones and Behaviour 94, 124-134 DOI.org/10.1016/j.yhbeh.2017.07.002.

Mirhosseini, N.Z., Knaus, S.J., Bohaychuk, K., Singh, J., Vatanparast, H.A., Weber, L.P. 2016. Both high and low plasma levels of 25-hydroxy-vitamin D have adverse cardiovascular effects in a normal rat model. British Journal of Nutrition 116(11), 1889-1900 DOI 10.1017/S0007114516004098.

Wildemann, T.M., Siciliano, S.D., Weber, L.P. 2016. The mechanisms associated with development of hypertension after exposure to lead, mercury species or their mixtures differs with the metal and the mixture ratio. Toxicology 339, 1-8. DOI 10.1016/j.tox.2015.11.004.

Nair, N., Gerger, C., Hatef, A.Z., Weber, L.P., Unniappan, S. 2016. Ultrasonography reveals in vivo dose-dependent inhibition of end systolic and diastolic volumes, heart      rate and cardiac output by nesfatin-1 in zebrafish. General Comparative Endocrinology 234, 142-150. DOI 10.1016/j.ygcen.2016.02.015.

Wildemann, T.M., Siciliano, S.D., Weber, L.P. 2016. The mechanisms associated with development of hypertension after exposure to lead,  mercury species or their mixtures differs with the metal and the mixture ratio. Toxicology 339, 1-8 DOI 10.1016/j.tox.2015.11.004.

Panahifar, A., Swanston, T.M., Pushie, M.J., Belev, G., Chapman, D., Weber, L.P., Cooper, D.L.M. 2016. Three-dimensional labeling of newly formed bone using synchrotron radiation barium K-edge subtraction imaging. Physics in Medicine and Biology 61, 5077-5088 DOI:10.1088/0031-9155/61/13/5077.

Gerger, C.J., Weber, L.P. 2015. Comparison of the acute effects of benzo-a-pyrene on adult zebrafish (Danio rerio) cardiorespiratory      function following intraperitoneal injection versus aqueous exposure. Aquatic Toxicology 165, 19-30. DOI 10.1016/j.aquatox.2015.05.008.

Adolphe, J.L., Drew, M.D., Silver, T.I., Fouhse J., Childs, H., Weber L.P. 2015. Effect of an      extruded pea or rice diet on post-prandial insulin responses and cardiovascular health in obese dogs. Journal of Animal Physiology & Animal Nutrition 99:4, 767-776. DOI:10.1111/jpn.12275.

Wildemann, T.M., Weber, L.P.,      Siciliano, S.D. 2015. Combined exposure to lead, inorganic mercury and      methylmercury shows deviation from additivity for cardiovascular toxicity      in rats.  Journal      of Applied ToxicologyDOI 10.1002/jat.3092.

Gerger, C.J., Thomas, J.K., Janz, D.M., Weber, L.P. 2015. Effects of acute β-naphthoflavone on cardiorespiratory function and metabolism in adult zebrafish (Danio rerio). Fish Physiology & Biochemistry 41, 289-298 DOI 10.1007/s10695-014-9982-z.

Gerger, C.J., Thomas, J.K., Janz, D.M., Weber, L.P. 2015. Affects of acute β-naphthoflavone on cardiorespiratory function and metabolism in adult zebrafish (Danio rerio). Fish Physiology & Biochemistry 41, 289-298 DOI 10.1007/s10695-014-9982-z.

Adolphe, J.L., Drew, M.D., Silver, T.I., Fouhse J., Childs, H., Weber L.P. 2015. Effect of an extruded pea or rice diet on post-prandial insulin responses and cardiovascular health in obese dogs. Journal ofAnimal Physiology & Animal Nutrition DOI: 10.1111/jpn.12275.

Wildemann, T.M., Weber, L.P., Siciliano, S.D. 2015. Combined exposure to lead, inorganic mercury and methylmercury shows deviation from additivity for cardiovascular toxicity in rats.  Journal of Applied ToxicologyDOI 10.1002/jat.3092.

Wildemann, T.M., Mirhosseini, N.M., Siciliano, S.D., Weber, L.P. 2015. Cardiovascular responses to lead are biphasic, while methylmercury, but not inorganic mercury, monotonically increases blood pressure in rats. Toxicology 328, 1-11 DOI 10.1016/j.tox.2014.11.009.

Gerger, C.J., Weber, L.P. 2015. Comparison of the acute effects of benzo-a-pyrene on adult zebrafish (Danio rerio) cardiorespiratory function following intraperitoneal injection versus aqueous exposure. Aquatic Toxicology 165, 19-30. DOI 10.1016/j.aquatox.2015.05.008.

Adolphe, J.L., Silver, T.I., Childs, H., Drew, M.D., Weber L.P. 2014. Short-term obesity results in detrimental metabolic and cardiovascular changes that may not be reversed with weight loss. British Journal of Nutrition. 112, 647-656.