Hecker, Markus

Associate Professor and Canada Research Chair in Predictive Aquatic Ecotoxicology

Markus Hecker

Associate Professor and Canada Research Chair in Predictive Aquatic Ecotoxicology
Toxicology Centre
University of Saskatchewan, 44 Campus Drive
Saskatoon, Saskatchewan, Canada
S7N 5B3

Phone: (306) 966-5233

Email: markus.hecker@usask.ca


Academic Degrees

  • Diploma, Ph.D. (University of Hamburg, Germany)

Current Teaching

  • Aquatic Toxicology (TOX 850)

Current and Recent Research Projects

  • Environmental risk assessment of classic (e.g. dioxins/dibenzofurans, PCBs, metals) and emerging (e.g. pesticides, endocrine disrupters) pollutants.
  • Ecotoxicology of endocrine active compounds in fish, amphibians and other wildlife.
  • Development and application of bioanalytical techniques to address (eco‑)toxicological issues.
  • International (OECD) and national (EPA) validation programs for endocrine disruptor screening assays.
  • Toxicological assessment of dioxins/dibenzofurans, pesticides and metals in fish, amphibians and mammals.

Publications

Woelz, J., Cofalla, C., Hudjetz, S., Roger,S., Brinkmann, M., Schmidt, B., Schaeffer, A., Kammann, U., Lennartz, G., Hecker, M., Schuettrumpf, H., Hollert, H. 2008. In search for the ecological and toxicological relevance of sediment re-mobilization and transport during flood events.  J Soils Sediments. In press.

Park, J., Tompsett, A.R., Zhang, X., Newsted, J.L., Jones, P.D., Yu, R., Wu, R.S.S., Kong, R.Y.C., Giesy, J.P., Hecker, M. 2008a. Fluorescence in situ hybridization techniques (FISH) to detect changes in CYP19a gene expression of Japanese medaka (Oryzias latipes). Toxicol. Appl. Pharmacol. 232:226-235.

Hecker, M., Giesy, J.P. 2008. Novel trends in endocrine disruptor testing:  the H295R Steroidogenesis Assay to identify inducers and inhibitors of hormone production. Anal. Biochem. Chem., in press.

Hecker, M., Hollert, H., Cooper, R., Vinggaard, A.-M., Akahori, Y., Murphy, M., Nellemann, C., Higley, E., Newsted, J., Wu, R., Lam, P., Laskey, J., Buckalew, A., Grund, S., Nakai, M., Timm, G., Giesy, J. 2007. The OECD Validation Program of the H295R Steroidogenesis Assay for the Identification of In Vitro Inhibitors and Inducers of Testosterone and Estradiol Production. Phase 2: Inter-Laboratory Pre-Validation Studies. Env. Sci. Pollut. Res. 14 (Special Issue 1): 23-30.

Villeneuve, D.L., Ankley, G.T., Makynen, E.A., Blake, L.S., Greene, K.J., Higley, E.B., Giesy, J.P., Hecker, M. 2007. Comparison of a fathead minnow ovarian steroidogenesis assay and an H295R cell-based steroidogenesis assay for identifying endocrine active chemicals. Ecotox. Environ. Saf. 68: 20-32.

Murphy, M.B., Hecker, M., Coady, K.K., Tompsett, A.R., Jones, P.D., DuPreez, L.H., Everson, G.J., Solomon,  K.R., Carr, J.A., Smith, E.E., Kendall, R.J., van der Kraak, G. and Giesy, J.P. 2005. Atrazine concentrations, gonadal gross morphology and histology in ranid frogs collected in Michigan agricultural areas. Aquat. Toxicol. 76: 230-245.

Hecker, M., Park, J.-W., Murphy, M. B., Jones, P.D., Thompset, A., Solomon, K.R., Van Der Kraak, G., Carr, J.A., Smith, E.E., du Preez, L., Kendall, R.J. and Giesy, J.P.  2005. Effects of atrazine on CYP19 gene expression and aromatase activity in testes and sex steroid concentrations in plasma of male African clawed frogs (Xenopus laevis). Tox. Sci. 86(2): 273-280.

Hecker, M. and Karbe, L. 2005. Parasitism in fish - an endocrine modulator of relevance? Aquat. Toxicol. 72: 195-207.