Paterson, Phyllis

Professor

Phyllis Paterson

College of Pharmacy and Nutrition
University of Saskatchewan, 110 Science Place
Saskatoon, Saskatchewan, Canada
S7N 5C9

Phone: (306) 966-5838

Email: phyllis.paterson@usask.ca


Academic Degrees

  • B.S.H.Ec., M.Sc. (Saskatchewan), Ph.D. (Guelph)

Current Teaching

  • NUTR 440.6  Clinical Nutrition
  • NUTR 810.3 Advances in Human Nutritional Sciences Research

Current and Recent Research Projects

Stroke, a reduction in blood flow to a region of the brain, is a major cause of death and disability in North America. We are studying the potential for pre- and post- ischemic nutritional status (e.g. protein-energy malnutrition) to influence the extent of disability following stroke and the mechanisms by which such effects can be exerted. The effects of nutrients on antioxidant defense during the acute period following stroke and the neuroplastic events of the subsequent recovery period are studied.


Publications

Hackett MJ, Smith SE, Caine S, Nichol H, George GN, Pickering IJ, Paterson PG. Novel bio-spectroscopic imaging reveals disturbed protein homeostasis and thiol redox with protein aggregation prior to hippocampal CA1 pyramidal neuron death induced by global brain ischemia in the rat. Free Radic Biol Med. 2015 Dec;89:806-18.

Alaverdashvili M, Li X, Paterson PG. Protein-Energy Malnutrition Causes Deficits in Motor Function in Adult Male Rats. J Nutr. 2015 Nov;145(11):2503-11.

Alaverdashvili M, Paterson PG, Bradley MP. Laser system refinements to reduce variabilityin infarct size in the rat photothrombotic stroke model. J Neurosci Methods. 2015 May 30;247:58-66.

Hackett MJ, Britz CJ, Paterson PG, Nichol H, Pickering IJ, George GN. In situbiospectroscopic investigation of rapid ischemic and postmortem induced biochemical alterations in the rat brain. ACS Chem Neurosci. 2015 Feb 18;6(2):226-38.

Smith SE, Figley SA, Schreyer DJ, Paterson PG. Protein-energy malnutrition>developing after global brain ischemia induces an atypical acute-phase response and hinders expression of GAP-43. PLoS One. 2014 Sep 26;9(9):e107570.

Alaverdashvili M, Hackett MJ, Pickering IJ, Paterson PG. Laminar-specific distribution of zinc: evidence for presence of layer IV in forelimb motor cortex in the rat. Neuroimage. 2014 Dec;103:502-10.

Smith SE, Ramos RA, Refinetti R, Farthing JP, Paterson PG. Protein-energy malnutrition induces an aberrant acute-phase response and modifies the circadian rhythm of core temperature. Appl Physiol Nutr Metab. 2013 Aug;38(8):844-53.8

Hackett MJ, Borondics F, Brown D, Hirschmugl C, Smith SE, Paterson PG, Nichol H, Pickering IJ, George GN. Subcellular biochemical investigation of Purkinje neurons using synchrotron radiation fourier transform infrared spectroscopic imaging with a focal plane array detector. ACS Chem Neurosci. 2013 Jul 17;4(7):1071-80.

Hackett MJ, Borondics F, Brown D, Hirschmugl C, Smith SE, Paterson PG, Nichol H, Pickering IJ, George GN. Subcellular biochemical investigation of Purkinje neurons using synchrotron radiation fourier transform infrared spectroscopic imaging with a focal plane array detector. ACS Chem Neurosci. 2013 Jul 17;4(7):1071-80.

Dubyk MD, Card RT, Whiting SJ, Boyle CAJ, Zlotkin SH,Paterson PG. Iron deficiency anemia prevalence at first stroke or transient ischemic attackCanadian Journal of Neurological Sciences39: 189-195, 2012.

Auriat AM, Silasi G, Wei Z, Paquette R,Paterson PG,Nichol H, Colbourne F.Ferric iron chelation lowers brain iron levels after intracerebral hemorrhage in rats but does not improve outcome.Experimental Neurology234: 136-143, 2012.

Smith SE, Prosser-Loose EJ, Colbourne F,Paterson PG Protein-energy malnutrition alters thermoregulatory homeostasis and the response to brain ischemia. 
Current Neurovascular Research
. 2011 Jan 5. [Epub ahead of print]

Prosser-Loose, E.J., Verge, V.M.K., Cayabyab, F.S., andPaterson, P.G.Protein-energy malnutrition alters hippocampal plasticity-associated protein expression following global ischemia in the gerbil.Current Neurovascular Research 7:341-60, 2010.

McEwen, B. R. and Paterson, P.G. Caloric restriction provided after global ischemia does not reduce hippocampal CA1 injury or improve functional recovery. Neuroscience 166: 263-270, 2010.

Ji, J., Nazarali, A.J., and Paterson, P.G. Protein-energy malnutrition increases activation of the transcription factor, nuclear factor kappa B, in the gerbil hippocampus following global ischemia. Journal of Nutritional Biochemistry 19: 770-777, 2008.

Prosser-Loose, E.J, Saucier, D.M., and Paterson, P.G. Can a reward-based behavioral test be used to investigate the effect of protein-energy malnutrition on hippocampal function? Nutritional Neuroscience 10: 145-150, 2007.

Prosser-Loose, E.J. and Paterson, P.G. The FOOD Trial Collaboration: Nutritional supplementation strategies and acute stroke outcome.Nutrition Reviews 64: 289-294, 2006.