McGurn, Leah


Leah McGurn

Toxicology Centre
Drug Discovery & Development Research Group
107 Wiggins Rd, University of Saskatchewan
Saskatoon, SK Canada S7N 5E5


Current and Recent Projects

Secoisolarisirensinol (SECO) is a lignan with many potential health benefits including: a reduction in serum cholesterol levels, delaying the onset of type II diabetes and decreased formation of cancers.  The major metabolite of SECO in metabolism studies is lariciresinol, which is likely formed as a result of para-quinone methide (p-QM) formation followed by an intramolecular cyclization; minimizing any toxicity associated with the formation of a p-QM.  Four analogues of SECO with altered functional groups were synthesized and are being used to investigate the effect of structure on the metabolism of SECO.  This will lead to an increased understanding of the pharmacological and toxicological properties of lignans.


McGurn, L.M and Krol, E.S. 2014 Oxidative metabolism of Secoisolariciresinol Analogues. Poster Presentation. 2014 Toxicology Group AGM