University of Saskatchewan

 

The Toxicology Group

The Toxicology Group is an interdisciplinary body under the umbrella of the College of Graduate Studies and Research. It consists of faculty members from a number of University departments, as well as scientists from various research centres on campus. The Toxicology Group is coordinated and managed by the Toxicology Centre.  Scientists with academic or research interests in toxicology who work at the University of Saskatchewan or any of the federal or provincial agencies or private sector laboratories on or near campus, are eligible to become members of the Group. Two types of membership may be granted: members are those currently involved in research or teaching specifically related to toxicology; associate members are those who have a principal interest in toxicology, but are not presently engaged in active research or teaching in the field of toxicology.

The mandate of the Group is to: maintain and support academic programs in toxicology at the University of Saskatchewan; promote and facilitate research in toxicology; promote public awareness and engage in community consultation on important issues in the area of toxicology; and to work cooperatively and collaboratively with all academic units participating in toxicology and address difficulties when they arise in matters involving shared resources. The Group is headed by a Chair, who is the Director of the Toxicology Centre, or his or her designate. The Chair is assisted by an Executive Committee, elected every three years by the membership. The Executive Committee consists of an Academic Coordinator, two members-at-large elected by the membership, one member-at-large elected by the Toxicology Centre, and the Dean, College of Graduate Studies and Research (ex officio).  Members of the Toxicology Group are eligible to serve as supervisors for students enrolled in M.Sc. and Ph.D. programs in Toxicology. They are actively engaged in research across a broad spectrum of toxicology sub-disciplines. The following is a brief description of Toxicology Group members' primary research interests within sub-disciplines of toxicology.

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Academic and Research Faculty 

Analytical and Forensic Toxicology
George, G. Sulfur K-edge X-ray absorption spectroscopy as a probe of sulfur biochemistry in intact tissues.
Headley, J. Environmental mass spectrometry. (Environment Canada) 
Hudson, J.C. Forensic toxicology; development of newer and faster methods for forensically significant analytes. (Royal Canadian Mounted Police) 
McKay, G. Development and application of high sensitivity analytical procedures with focus on pharmaceuticals. 
Nazarali, A.J. Teratogenicity; DNA-protein interactions; transcriptional factors; expression of developmental genes in mice embryos. 
Wang, D. Analytical, environmental, and drinking water quality.
Wang, X. Analytical (inductively coupled plasma mass spectroscopy) and environmental toxicology.

Biomedical and Human Toxicology 
Alcorn, J. Infant exposure to xenobiotics; maturation of clearance mechanisms; toxicokinetics.
Berry, M. Endogenous regulators of CNS neuronal activity; cell death mechanisms in neurones; regulation of cell death in normal and cancer cells.
Bharadwaj, L. Cardiovascular toxicology.
Blakley, P. Clinical teratology; Fetal Alcohol Syndrome; genetic predisposition to teratogenesis.
Hiebert, L.M. Vascular biology/toxicology; injury by free radicals. 
Krol, E. Xenobiotic metabolism of naturally occuring phenols; reactive intermediates.
Krone, P. Endocrine modulation/developmental toxicology; use of stress proteins as biomonitors of toxicity in fish embryos.
Lehotay, D. The role of free radicals in the pathophysiology of disease. (Sask. Health)
Paterson, P. Biochemical and physiological functions of trace elements; nutrition and eye function; effects of nutrients on antioxidant pathways in stroke.
Qureshi, A.M. Clinical toxicology and therapeutic drug monitoring; drugs of abuse; homocystine; immunosuppresive drugs.
Rosenberg, A. Environmental toxin exposure and induction of autoimmunity.
Singh, B. Nanotoxicology and nanomedicine; molecular mechansisms of lung inflammation.
Weber, L Tobacco smoke and air pollution effects on cardiovascular disease; pathophysiological mechanisms, animal models, role of polycyclic aromatic hydrocarbon
Whiting, S. Nutritional toxicology; diet and osteoporosis, with emphasis on nutrition-bone relationship; safety of foods produced through biotechnology; dietary fibre.
Xiao, W. Mechanisms of action of genotoxic chemicals and cellular responses to DNA damage. 
Zello, G.A. Protein and amino acid metabolism in humans and animals investigated using stable isotope methodology; effects of drugs on protein metabolism, drug-nutrient interactions. 
Veterinary and Wildlife Toxicology
Blakley, B.R. Immunotoxicology - environmental aspects, nutritional states; applied veterinary toxicology; heavy metal toxicity (Pb, Cd). 
Bortolotti, G.R. Lead poisoning in birds; avian immunotoxicology. 
Leighton, F.A. Wild animal disease surveillance, including poisonings; diagnosis of anti-cholinesterase pesticide poisoning; petroleum oil toxicity to birds.
Morrissey, C. Avian ecology and ecotoxicology. Testing biomarkers of exposure (ecophysiological, stable isotopemethods) and effects of pollutants in wild birds.
Somer, S. Environmental exposures and DNA damage in wildlife and indicator species. Processes in the germline that contribute to trans-generational effects due to contaminant exposure.
Wickstrom, M.L. Effects of pesticides and metals in wildlife; cyanobacterial toxins; clinical veterinary toxicology; environmental risk assessment. 
Ecological and Aquatic Toxicology  
Cessna, A. Atmospheric transport and fate of pesticides; transport of pesticides in runoff waters and subsurface waters. (Environment Canada) 
Davies, J-M. Nutrient impacts on algal ecology; drinking water quality. (Saskatchewan Watershed Authority)
Evans, M.S. Biomagnification of persistent organochlorines and mercury. (Environment Canada) 
Farrell, R. Metal speciation/bioavailability in soils and sediments; phytoremediation systems for TPH and metal contaminated sites.
Giesy, J. Discovery and assessment of emerging contaminants of concern, including perfluorinated compounds (PFCs); development of novel bioanalytical tools; biochemical indicators of stress in aquatic organisms; and assessment of endocrine modulating compounds.
Hecker, M. Development, validation and application of novel bioanalytical techniques; endocrine disruption and reproductive toxicology in oviparous vertebrates; ecotoxicological risk assessment of persistent organic compounds, pesticides and metals in vertebrates.
Janz, D. Reproductive physiology and endocrinology of oviparous vertebrates; endocrine toxicity; biochemical toxicology; mechanisms of toxicity; cytochrome P450.
Jones, P. Fate and effects of organic pollutants in the evironment and wildlife. Use of biochemical and molecular biology techniques in environmental toxicology.
Liber, K. Metal bioavailability and toxicity in aquatic ecosystems, especially in sediments; mining impacts on aquatic ecosystems.
Niyogi, S Assessment of waterborne metal bioavailability and toxicity using the Biotic Ligand Model (BLM) approach; uptake, regulation, and toxicity of dietary metals in freshwater fish.
Raine, J. Developmental physiology and endocrinology; endocrine disruption; mechanisms of toxicity; thyroid hormone regulation and signaling
Siciliano, S.D. Soil ecotoxicology, investigation of trace contaminant effects in northern terrestrial ecosystems using molecular tools.
Thomas, P. Environmental transport and food chain transfer of radionuclides; radiation dosimetry and risk assessment; radiation biology of animal and human cell types.
Van Rees, K. Metal speciation in the soil rhizosphere; modelling of nutrient and cadmium uptake by plant roots. 
Wayland, M. Effects of non-pesticidal environmental contaminants on wildlife and their habitats; assessing temporal and spatial trends of contaminants in wildlife in the prairies and arctic regions.