Bachand, Nicholas, Epidemiology and Microbiology
Research Interests: The aim of the research project is to evaluate the risk of Toxoplasmosis through the consumption of infected wildlife in the Canadian Arctic using a One-Health approach.
For my Master's project I characterized the Large T antigen of the Myotis polyomavirus. Similar proteins in other polyomaviruses play a critical role in virus replication and immune evasion. For my PhD project I will characterize the antiviral responses of the little brown bat and how they are deployed against the Myotis polyoma and coronaviruses. I will then compare these findings with how human cells respond to the same viruses. It would be interesting to see if the degree of innate immune response varies between bats and other mammals. If it does, it would explain how bats maintain deadly viruses such as SARS and Ebola without being killed, whereas other mammals (non-human primates and humans) succumb to such viruses.
Bouchard, Emilie, Parasitology
Bridge, Rylan, Molecular Biology
Research Interests: We will be investigating the mechanism by which the cellular autophagy pathway leads to two distinct outcomes, cell death and cell survival, in human monocytes. Cell signalling events will be examined using a kinome microarray approach, and key areas of pathway divergence analyzed for functional relevance.
Costa, Matheus, Molecular Microbiology
Costa de Freitas, Aline, Microbiology
Research Interests: The complex microbial community present in the female lower genital tract is an important factor in women's reproductive health. Imbalances in this microbiota can lead to increased susceptibility to infectious diseases, bacterial vaginoisis, and negative outcomes such a preterm birth. However, our understanding of the causes of such variations is limited and the vaginal microbiota remains poorly characterized.
My research project is focused on determining if characteristic vaginal microbiome profiles are associated with pregnant women at low and high risk for preterm birth. The vaginal microbiota of pregnant women will be characterized using a combination of conventional microbiology and culture independent methods involving high throughput pryosequencing. Our goal is a better understanding of the relationship of the vaginal microbiome to women's health in pregnancy.
Research Interests: I am interested in studying the immune response in pig dendritic cells to the porcine reproductive and respiratory syndrome virus. I will determine the effects that variation in specific viral genes have on the immune response to PRRSV. Further elucidating the roles of the genes, in addition to studying the overall pathogenesis, will aid in the development of a vaccine candidate.
Elmore, Stacey, Parasite Ecology
Research Interests: Parasite ecology
Research Interests: Adenoviruses have become a popular tool for gene transfer into mammalian cells because of their properties like broad tropism, rapid growth to high titers in tissue culture and transgene carrying capacity of up to 30kb. Moreover adenoviral genome is easy to manipulate and it does not integrate into host chromosome thereby minimizing the risk of insertional mutagensis. In order to overcome limitations of human adenovirus vectors, a variety of non-human adenoviral vectors have been proposed as promising vector candidates. In addition to most of the attractive features of HAdV vectors, these vectors have several unique properties like species specificity, safety against inappropriate vector replication and providing the vector backbone without preexisting immune response. Our laboratory has been working on characterizing various gene products of BAdV-3 so that this information can be ultimately used for the development of BAdV-3 as an efficient vector for gene delivery.
Gamage, Ruwini Dharmasiri, Bacteriology
Research Interests: At present there is no standardized methods for conducting or interpreting antimicrobial susceptibility tests on Brachyspira. Therefore, the main obejctive of this study is to develop, standardize and implement antimicrobial susceptibility testing methods for Brachyspira spp. to improve the ability of the Canadian swine industry to combat Brachyspira-associated disease by providing evidence-based treatment recommendations.
Research Interests: The immune response in the genital track infection of pigs with Chlamydia trachomatis and the establishment of pigs as a model for the development of potential vaccine candidates.
Katyal, Isha, Molecular Biology
The aim of the project is to identify and characterize strain-specific differences in the microbiota of the pig intestine and study the effects of various factors such as time, development and diet on strain level population dynamics in the pig intestine. The results will help us understand niche specialization and the selective and evolutionary forces that shape complex microbial communities.
Li, Chunyan, Immunology
Based on previous studies, we hypothesize that the endogenous lung dendritic cells in DCIL10-treated asthmatic mice take on a regulatory phenotype and participate in infectious tolerance pathways involving T cells, and both treatment and endogenous dendritic cells. This study will help to understand the mechanism of DCIL10 tolerance induction in asthma and provide a theoretical foundation for further clinical therapy.
Paramel, Teenus, Molecular Biology
The goal of our team is to determine if there is a "core" vaginal microbiome shared by clinically healthy women of reproductive age. We will characterize the vaginal microbiota of women through the menstrual cycle using culture independent methods involving high through-put pyrosequencing of DNA from samples of the microbiota. The results of these studies will create a baseline resource for future studies focused on understanding the relationship between vaginal microbial population structure and pre-term birth.
Park, Hong-su, Molecular Virology
Pastl, Kimberley, Bacteriology/Immunology
Research Interests: Histophilus Somni is an important member of the bovine respiratory disease complex. The vaccines currently in use are killed whole cell bacterins based on strains isolated decades ago, with one vaccine including antigens such as the iron-regulated outer membrane proteins. These proteins are secreted through the TonB-dependent transport system, which are common in Gram-negative organisms, and have been shown to be protective antigens in other species. I hypothesize that vaccination with TonB-dependent proteins produced by H. somni will be protective against experimental infection if a vaccine formula capable of inducing cellular immunity is used.
Research Interests: Attenuation of Brachyspira
Research Interests: My research will focus on Methicillin Resistant Staphylococcus Pseudintermedius. The study consists of isolation, identification, antibiotic resistant gene identification of associated virulence gene of MRSP from different clinical isolates.
Sachdeva, Rohini, Molecular Virology
Research Interests: The role of neutralizing antibodies in PRRSV infection
Research Interests: Janna Schurer works with remote and Aboriginal northern communities to determine prevalence of parasites in pets, wildlife, and exposure risk to humans. She specifically focuses on Echinococcus granulosus, which is a zoonotic tapeworm of human health concern, as well as Baylisascaris, Diphyllobothrium, Toxocara, and Giardia. Other interests include providing veterinary services to remote communities, as well as introducing dog population control measures that are sustainable and humane. Once finished her graduate work, she hopes to return to the jungles of Asia to continue her work with elephants and indigenous peoples.
Research Interests: Characterization of Trichinella and Toxoplasma in wildlife and domestic animals.
Research Interests: Biogas produced using anaerobic digestion of agricultural biomass is becoming a more popular and economically viable source of energy. If sufficiently optimized, the system can be cost effective, environmentally sustainable and carbon neutral.
We are presently characterizing the microbial consortia present in anaerobic digesters processing a combination of distillery waste products and cattle manure. By determining the microbial profiles associated with high-performing digesters, we hope to manipulate operating conditions to increase production and efficiency.
Wittrock, Julie, Wildlife Epidemiology
Adapting a cumulative effects approach for evaluating wildlife health and investigating the feasibility of its practical application.
Research Interests: My research focuses on assessing the effect of Bovine Adenovirus-3 on ribosome biogenesis. In cells of Bovine origin, infected with the virus, cellular ribosome biogenesis will be examined using various experimental approaches. In addition, the role of viral proteins in the cellular ribosome biogenesis will be examined.
Research Interests: My main project is molecular pathogenesis of HBV HCV co-infection. Because these two viruses have the same modes of transmission, HBV HCV co-infection is found in approximately 7 - 20 million people globally. This research will make a significant contribution to prevent the high risk of development of HCC in HBC HCV co-infection patients.