Translational Research Models
The Western College of Veterinary Medicine is a key
component of the University of Saskatchewan's life sciences research and
training cluster of colleges. The concept of "One world, one health, one
medicine" is reflected in the College's integrated plan, and it's an approach
that the veterinary college is building on to create more connections between
animal health, human health and ecosystem health.
Throughout its history, WCVM researchers have been
highly effective in using models of anatomy, physiology, disease or drug
therapies, research teams to make valuable advances in animal and human health.
For example, WCVM faculty members have developed translational research models
in areas such as reproduction where bovine models have helped scientists learn
more about ovarian function and follicular dynamics in both animals and
humans. Researchers are also learning
more about the manipulation of spermatogenesis for human therapies through the
use of animal models.
In the area of neurophysiology, rat models are helping
research teams learn more about the effects of central nervous system disease
or injury on the sensorimotor behaviour of humans as well as animals. Testing
the effectiveness of antithrombotic drugs, such as heparin, in dogs is helping
scientists learn more about their pharmocodynamics and use in humans. In the
area of infectious diseases, an intensive investigation of West Nile virus in horses
helped to shed light on the disease's epidemiology in Western Canada.
In the area of environmental
toxicology, swine, fish and canine models are helping researchers learn more
about the effect of environmental toxicants on the cardiovascular system.
Translational research models are also highly effective in the areas of
ophthalmology and oncology where human and veterinary scientists can equally
gain fresh perspectives on the pathogenesis of disease as well as treatment,
early detection and prevention.
- Adams, Gregg
Basic and applied aspects of reproductive science and medicine. Dr. Adams' current projects include the characterization of reproductive events in wapiti and white-tailed deer, ovulation-inducing factors in llamas and alpacas, factors influencing oocyte competence in cattle, and synchrotron-based biomedical imaging of reproductive tissues.
- Forsyth, George
The activity of ion transport proteins involved in the pathology of diarrheal diseases and cystic fibrosis.
- Gerdts, Volker
Development of neonatal vaccines; innate immunity at the respiratory surfaces (antimicrobial peptides); basic mechanisms of intestinal immunity; lymphocyte trafficking; mucosal immunology; chemokines; enteric infections; and knowledge transfer of basic research into applied clinical research and producers.
- Gordon, John
Immunology and immunopathology, particularly examining allergic disease and inflammation.
- Hiebert, Linda
Cardiovascular research, including the pharmacodynamics of orally administered heparins and related polyanions, and damage and protection of endothelial cells.
- Hill, Janet
Microbial ecology, livestock and human disease,
phylogenetics and taxonomy, molecular diagnostics and development of cpnDB, a
chaperonin sequence database.
- Honaramooz, Ali
Reproductive biology and technology, with emphasis on the study and manipulation of spermatogenesis and spermatogonial stem cells.
- Liu, Qiang
Elucidating molecular mechanisms of viral pathogenesis. Special research areas are human hepatitis viruses (such as hepatitis C virus) and porcine circoviruses.
- Loewen, Matthew
Investigations of the mechanism and effects of calcium activated chloride channels as they modulate human and animal diseases.
- Mayer, Monique
Veterinary radiation oncology.
- Muir, Gillian
The changes in sensorimotor behaviour that occur during normal development or after central nervous system injury or disease.
- Potter, Andrew
Application of genomics to the animal health field. Dr. Potter's work also focuses on forging links between the animal and human infectious disease research communities to ensure that technologies common to both fields can be leveraged to their greatest benefit.
- Rawlings, Norman
Basic and applied aspects of the regulation of ovarian folliculogenesis in sheep, and reproductive maturation in beef cattle.
- Singh, Baljit
Cell and molecular biology of lung inflammation. Dr. Singh's projects focus on mechanisms of neutrophil and monocyte migration into inflamed lungs, biology of pulmonary intravascular macrophages and environmental pulmonary toxicology.
- Singh, Jaswant
The use and further development of the bovine model for the study of ovarian function in humans. Dr. Singh's current and past research has been directed towards studying the ultrasonographic, morphologic and biochemical kinetics of ovarian follicles to refine the bovine model.
- Townsend, Hugh
Infectious disease epidemiology, vaccine formulation, delivery and efficacy; and the immune response to infection. Dr. Townsend's recent research focuses on the investigation of a foal's immune response and its susceptibility to Rhodococcus equi pneumonia.
- Zhou, Yan
Molecular biology, pathogenesis and vaccine development of influenza virus.