 | Ayalew, Lisanework |
Genetic manipulation of microbes to adapt them as vectors for gene delivery offers a unique opportunity for vaccine design. Some key features of viral vectors are that they can elicit a strong humoral and cell-mediated immune response, which result in an immunological memory towards the gene in question.
Several replication-competent or replication-defective nonhuman adenoviral vectors have been developed and investigated for their potential as vaccine-delivery vectors. A better understanding of the biology of vectors will enable for designing and producing efficient and safe faccine delivery systems. My project envisions investigating the role of polypeptid.
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