University of Saskatchewan

Western College of Veterinary Medicine

Gaba, Amit

Graduate Student
Veterinary Microbiology
Office Location: VIDO (Vaccine and Infectious Disease Organization)
Phone: (306) 966-7508
Email: amg340@mail.usask.ca


Profile


Academic Credentials


Research Interests

Adenoviruses have become a popular tool for gene transfer into mammalian cells because of their properties like broad tropism, rapid growth to high titers in tissue culture and transgene carrying capacity of up to 30kb.  Moreover, adenoviral genome is easy to manipulate and it does not integrate into host chromosome thereby minimizing the risk of insertional mutagenesis.  In order to overcome limitations of human adenovirus vectors, a variety of non-human adenoviral vectors have been proposed as promising vector candidates.  In addition to most of the attractive features of HAdV vectors, these vectors have several unique properties like species specificity, safety against inappropriate vector replication and providing the vector backbone without preexisting immune response.  Our laboratory has been working on characterizing various gene products of BAdV-3 so that this information can be ultimately used for the development of BAdV-3 as an efficient vector for gene delivery.