University of Saskatchewan

Western College of Veterinary Medicine

Gordon, John

Associate Member
Veterinary Microbiology
Phone: 306-966-1901


Photo: Saskatchewan Health Research Foundation/Debra Marshall Photography

Academic Credentials

Research Interests

Dr. Gordon's research interests include immunology and immunopathology. Areas of special interest and research are tolerance induction in allergy/asthma, cytokines, regulation of immune responses, therapeutic amelioration of neutrophilic inflammation - each in human and veterinary species.

For more information about Dr. Gordon's research program, please visit his website.


Books, chapters and reviews:

J.R. Gordon, Y. Ma, L. Churchman, S.A. Gordon and W. Dawicki.  2014.  Regulatory dendritic cells for immunotherapy in immunologic diseases.  Frontiers in Immunology 5: 7 (12 pp; doi: 10.3389/fimmu.2014.00007)

S.J. Reynolds, M.W. Nonnenmann, I. Basinas, M. Davidson, L. Elfman, J.R. Gordon, S. Kirychuck, S. Reed, J. Schaeffer, M. Schenker, V. Schlunssen, and T. Sigsgaard.  2013. Systematic review of respiratory health among dairy workers.  J Agromedicine 18:219-43

Research reports:

M. Khan, B. Wang, J. Wei, Y Zhang, Q. Li, X. Luan, J-W. Cheng, J.R. Gordon, F. Li, and H. Liu. CXCR1/2 antagonism with a CXCL8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumour cell proliferation and suppressing angiogenesis. Oncotarget, submitted Jan 29, 2015

D Schneberger, JR Gordon, AJ Heires, JD DeVasure, JA Boten, DJ Romberger, TA Wyatt. 2015. CXCR1/CXCR2 antagonist CXCL8(3-74)K11R/G31P blocks lung inflammation in swine barn dust-instilled mice. Pulmonary Pharmacology and Therapeutics 31:55-62

P. Novakovic, Y.Y. Huang, B. Lockerbie, F. Shahriar, J. Kelly, J.R. Gordon, D.M. Middleton, M.E. Loewen, B.A. Kidney, and E. Simko. 2015. Identification of F4ac-binding proteins of porcine milk fat globule membranes.  Canadian Journal of Veterinary Research 79:120-8

L. Li, MN Khan, Q Li, X Chen, J Wei, B. Wang, J-W Cheng, JR Gordon and F Li. 2015. G31P, CXCR1/2 inhibitor, with cisplatin inhibits the growth of mice hepatocellular carcinoma and mitigates high‑dose cisplatin-induced nephrotoxicity. Oncol. Reports 33:751-7

S.A. Ballendine, Q. Greba, W. Dawicki, X. Zhang, J.R. Gordon, J.G. Howland. 2015.  Behavioral alterations in rat offspring following maternal immune activation and ELR-CXC chemokine receptor antagonism during pregnancy: implications for neurodevelopmental psychiatric disorders. Progress in Neuro-psychopharmacology & Biological Psychiatry 57:155-65

J. Wei, X Chen, Q Li, J Chen, N Khan, B. Wang, J-W Cheng, JR Gordon and F Li. ELR-CXC chemokine antagonism and cisplatin co-treatment additively reduce H22 hepatoma tumor progression and ameliorate cisplatin-induced nephrotoxicity.  2014.  Oncol. Reports 31(4):1599-604

M. Du, Q Qiu, A Gruslin, JR Gordon, M He, CC Chan, D Li, BK Sang. 2013. SB225002 promotes mitotic catastrophe in chemo-sensitive and -resistant ovarian cancer cells independent of p53 status in vitro. PLoS One. 2013;8(1):e54572. doi: 10.1371/journal.pone.0054572

J Wei, J Peng, B Wanh, H Qu, S Wang, A Faisal, JW Cheng, JR Gordon, F Li. 2013. CXCR1/CXCR2 antagonism is effective in pulmonary defense against Klebsiella pneumoniae infection. Biomed Res Int. 2013:720975. doi: 10.1155/2013/72097

H. Huang, Dawicki W, Zhang X, and Gordon JR.  2013. Comparison of induced versus natural regulatory T cells of the same TCR specificity for induction of tolerance to an environmental antigen.  Journal of Immunology 191:1136-43.

H Huang, W. Dawicki, M. Lu, X. Zhang, and J.R. Gordon.  2013. Requisite roles for MHC II and IL-10 expression for induction of tolerance by regulatory dendritic cells in asthma.  Allergy 68:1126-35.

C. Davidson, M. Asaduzzaman, NG Arizmendi, D. Polley, Y. Wu, J.R. Gordon, M. Hollenberg, L. Cameron and H. Vliagoftis. Proteinase-activated receptor-2 activation participates in allergic sensitization to house dust mite allergens in a murine model. Clinical and Experimental Allergy 43:1274-85.

Reid J, Taylor-Gjevre R, Gjevre J, Skomro R, Cotton D, F Olatunbosun, Fentor M, and Gordon JR.  2013.  Can Gestational Hypertension be modified by treating nocturnal airflow limitation? Journal of Clinical Sleep Medicine 15:311-17

Huang Y, Olson DJ, Gordon JR, Middleton DM, Simko E. 2012.  Plasma protein profiles of neonatal pigs before and after suckling.  Can J Veterinary Research 76:1-7

Nayyar A, Dawicki W, Huang H, Lu M, Zhang X, Gordon JR.  2012. Induction of prolonged asthma tolerance by IL-10-differentiated dendritic cells: differential impact on airway hyperresponsiveness and the Th2 immunoinflammatory response.  J Immunol 189:72-9.

Ahmed KA, Wang L, Munegowda MA, Mulligan SJ, Gordon JR, Griebel P, Xiang J. 2012.  Direct in vivo evidence of CD4+ T cell requirement for CTL response and memory via pMHC-I targeting and CD40L signaling.  J Leukocyte Biology 92:289-300.

Liu X, Peng J, Sun W, Yang S, Deng G, Li F, Cheng JW, Gordon JR. 2012.  G31P, an Antagonist against CXC Chemokine Receptors 1 and 2, Inhibits Growth of Human Prostate Cancer Cells in Nude Mice.  Tohoku J Experimental Medicine 228:147-56.

C. Ebeling, J.R. Gordon and D. Adamko.  2011. Compound CVT-E002 attenuates allergen-induced airway inflammation and airway hyperresponsiveness, in vivo.  Molecular Nutrition and Food Research 55:1905-08.

H. Huang, W. Dawicki, X. Zhang, J.R. Town and J.R. Gordon. 2010.  Regulatory dendritic cells induce CD4+CD25+Foxp3+ T regulatory effector cell differentiation from CD4+CD25-Foxp3- precursors. J Immunology 185:5003-10.

M. Lu, X. Zhang, H. Huang, and J.R. Gordon. 2011. Induction of immunologic tolerance with IL-10-differentiated dendritic cells in a mouse model of house dust mite-induced asthma. Allergy 66:612-20.

J. Fox, J.R. Gordon and C.K. Haston.  2011.  Combined CXCR1/CXCR2 antagonism decreases radiation-induced alveolitis in the mouse. Radiation Research 175:657-64.

N.G. Arizmendi, M. Abel, K. Mihara, C. Davidson, D. Polley, A. Nadeem, T. El Mays, B.F. Gilmore, B Walker, J.R. Gordon, M.D. Hollenberg and H. Vliagoftis.  2011.  Mucosal allergic sensitization to cockroach allergens is dependent on proteinase activity and PAR2 activation.   Journal of Immunology 186:3164-72

J. Cleave, P.J. Willson, J.R. Town, and J.R. Gordon. 2010. Fractionation of swine barn dust and assessment of its impact on the respiratory tract following repeated airway exposure.  J Toxicology and Environmental Health 73:1090-1101

X. Zhao, J.R Town, X. Zhang, F. Li, W. Li, and J.R. Gordon.  2010. Blockade of neutrophil responses in aspiration pneumonia via ELR-CXC chemokine antagonism does not predispose to airway bacterial outgrowth. Pulmonary Pharmacology and Therapeutics 23:22-28.

R. Vig, J.R. Gordon, B. Thebaud, A. D. Befus, and H. Vliagoftis.  2010. The effect of early-life stress on airway inflammation in adult mice. Neuroimmunomodulation 17:229-39

X. Zhao, J. R. Town, A. Yang, X. Zhang, G. Sawicki, and J.R. Gordon. 2010.  A novel ELR-CXC chemokine antagonist reduces intestinal ischemia reperfusion-induced mortality, and local and remote organ injury.   Journal of Surgical Research 162:264-73.

X. Li, X Zhang, J Town, B Davis, DW Cockcroft, and JR Gordon. 2010.  Interleukin-10-treated dendritic cells tolerize autologous atopic Th2 cells via induction of regulatory T cells.  American Journal of Respiratory Cellular and Molecular Biology 42:190-99.