Huang, Hui Graduate Student, Asthma Immunotherapy Veterinary Microbiology Office Location: WCVM 2622 or WCVM 2685 Phone: 306-966-7239 or 306-966-7213 Email: h.huang@usask.ca

Profile

• PhD candidate
• Supervisor: Dr. John Gordon, Veterinary Microbiology
• Home community and country: Taian, China

Academic Credentials

• MD. College of Medicine, Fudan University, 1990 (The Former Shanghai Medical University), China
• MSc. Dept. of Immunology, College of Medicine, Fudan University, 1997 (The Former Shanghai Medical University), China

Research Interests

Asthma is a chronic inflammatory disorder of the airways that causes episodic wheezing and difficulty breathing. Our laboratory has established a mouse model of asthma and recently reported that administration of allergen-presenting bone marrow-derived DC generated in the presence of interleukin (IL)-10 (DCIL-10) to such ‘asthmatic’ mice abrogates their airway hyperresponsiveness (AHR), eosinophilia and Th2 responses.

We are testing the hypothesis that DCIL-10 secretes IL-10 and induce CD4+CD25+Foxp3+ T regulatory cells to inhibit Th2 response in mouse model of asthma, and that this involves the induction of infectious tolerance. Our work will further address the cellular and molecular mechanisms regulating this asthma tolerization by DCIL-10 and provide a theoretical foundation for future clinical immunotherapeutic approaches to the asthmatic patients.