Asthma is a chronic allergic disorder causing breathing difficulty in response to allergens. Severe asthma can be life threatening. Current treatment can relieve symptoms but are ineffective in modifying the progression of asthma. In our lab, previous studies have showed that interleukin (IL)-10 differentiated dendritic cells (DCIL-10) tolerized asthmatic mice and the tolerance is associated with upregulation of regulatory T cells function in the lung.
Based on previous studies, we hypothesize that the endogenous lung dendritic cells in DCIL10-treated asthmatic mice take on a regulatory phenotype and participate in infectious tolerance pathways involving T cells, and both treatment and endogenous dendritic cells. This study will help to understand the mechanism of DCIL10 tolerance induction in asthma and provide a theoretical foundation for further clinical therapy.