University of Saskatchewan

Western College of Veterinary Medicine

Liu, Qiang

Adjunct Professor
Veterinary Microbiology
Office Location: Room A336, Vaccine and Infectious Disease Organization (VIDO)
Phone: 306-966-1567 or 306-966-1579
Email: qiang.liu@usask.ca


Academic Credentials


Research Interests

Dr. Liu's research is on elucidating molecular mechanisms of viral pathogenesis. Special research areas are human hepatitis viruses (such as hepatitis C virus) and porcine circoviruses.

Publications

Zhu J, Brownlie R, Liu Q, Babiuk LA, Potter A, Mutwiri GK. 2009. "Characterization of bovine Toll-like receptor 8: Ligand specificity, signaling essential sites and dimerization." Molecular Immunology. 978-90.

Oem JK,Jackel-Cram C, Zhou Y, Shimano H, Babiuk LA, Liu Q. 2008. "Activation of sterol regulatory element binding protein-1c and fatty acid synthase transcription by hepatitis C virus non-structural protein-2." Journal of General Virology. 89:1225-1230.

Oem JK, Jackel-Cram C, Li Y, Kang H-N, Zhou Y, Babiuk LA, Liu Q. 2008. "Hepatitis C virus non-structural protein-2 activates interleukin-8 transcription through NF-kappaB." Archives of Virology. 153:293-301.

Li Y, Anderson DH, Liu Q, Zhou Y. 2008. "Mechanism of influenza A virus NS1 protein interaction with the p85beta, but Not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity." Journal of Biological Chemistry. 23397-409.

Oem JK, Xiang Z, Zhou Y, Babiuk LA, Liu Q. 2007. "Utilization of RNA polymerase I promoter and terminator sequences to develop a DNA transfection system for the study of hepatitis C virus internal ribosomal entry site-dependent translation." Journal of Clinical Virology. 40:55-59.

Jackel-Cram C, Babiuk LA, Liu Q. 2007. "Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype 3a core has a stronger effect than genotype 1b core." Journal of Hepatology. 46:999-1008. Highlighted by editorials: “Hepatitis C virus: The viral way to fatty liver”, Clément S, Negro F. Journal of Hepatology. 46:985-987, 2007; “Fatty liver in chronic hepatitis C infection: unravelling the mechanisms”, Oben JA, Paulon E. Gut.  56:1186-8, 2007.

Shin, Y. K. Liu, Q. Tikoo, S. K. Babiuk, L. A. Zhou, Y. (2007), Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation, J Gen Virol, 942-50.

Shin, Y. K. Li, Y. Liu, Q. Anderson, D. H. Babiuk, L. A. Zhou, Y. (2007), SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signalling pathway activation, J Virol.

Shin, Y. K. Liu, Q. Tikoo, S. K. Babiuk, L. A. Zhou, Y. (2007), Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K, J Gen Virol, 13-8.

Oem, J. K. Xiang, Z. Zhou, Y. Babiuk, L. A. Liu, Q. (2007), Utilization of RNA polymerase I promoter and terminator sequences to develop a DNA transfection system for the study of hepatitis C virus internal ribosomal entry site-dependent translation, J Clin Virol, 55-9.

Li, Y. P. Kang, H. N. Babiuk, L. A. Liu, Q. (2006), Elicitation of strong immune responses by a DNA vaccine expressing a secreted form of hepatitis C virus envelope protein E2 in murine and porcine animal models, World J Gastroenterol, 7126-35.

Zakhartchouk, A. N. Liu, Q. Petric, M. Babiuk, L. A. (2005), Augmentation of immune responses to SARS coronavirus by a combination of DNA and whole killed virus vaccines, Vaccine, 4385-91