Research in our laboratory focuses on two areas:
1. Pathogenesis of Pseudogymnoascus destructans, a fungus that has killed millions of bats in North America since its introduction in 2007, and the effect of fungal infection, as well other stressors, on the reactivation of a bat coronavirus closely related to viruses that have spilled over from bats into humans and other species.2. The role of Luman (CREB3) and Zhangfei (CREBZF) in herpesvirus biology, stress responses and neuronal repair.
Miller M, McMinn R, Misra V, Schountz T, Muller M, Kurth A, Munster VJ. Broad and temperature independent replication potential of Filoviruses on cell derived from old and new world bat species. J. Inf. Dis 2016 (accepted, May 6, 2016
McGuire LP, Turner JM, Warnecke L, McGregor G, Bollinger TK, Misra V, Foster JT, Frick WF, Kilpatrick AM, Willis CK. White-Nose Syndrome Disease Severity and a Comparison of Diagnostic Methods.Ecohealth. 2016 Mar 8.
Ying Z, Zhai R, McLean NA, Johnston JM, Misra V, Verge VM. The Unfolded Protein Response and Cholesterol Biosynthesis Link Luman/CREB3 to Regenerative Axon Growth in Sensory Neurons.J Neurosci. 2015 Oct 28;35(43):14557-70. [Impact factor 6.34]
Zhang R, Douglas, H. Thamm, Misra V. The effect of Zhangfei/CREBZF on growth, differentiation, apoptosis, migration and the Unfolded Protein Response in several canine osteosarcoma cell lines. 2015. BMC Vet. Res BMC Vet Res 11:22
N. Denk, V. Misra, L.E. Sandmeyer, B. Bauer, J. Singh, G.W. Forsyth, B. Grahn. Development and characterization of a murine retinal explant culture system as an in vitro model of retinal gene transfer. 2015. Can. Jn. Vet. Res. 79(1):31-8
Stephen C, Berezowski J, Misra V. Surprise is a Neglected Aspect of Emerging Infectious Disease. 2014. Ecohealth. Epub 2014 Dec 12. [Impact factor 2.45]
Turner JM, Warnecke L, Wilcox A, Baboon D, Bollinger TK, Misra V, Willis CKR. Conspecific disturbance contributes to altered hibernation patterns in bats with white-nose syndrome. 2014. Physiol. Behav. 140C:71-78.
Ying Z, Misra V, Valerie M K Verge. Sensing nerve injury at the axonal ER: activated Luman/CREB3 serves as a novel axonally synthesized retrograde regeneration signal. 2014. Proc Natl Acad Sci U S A Nov 27;111(45):16142-7.
Rapin N, Johns K, Martin L, Warnecke L, Turner JM, Bollinger TK, Willis CKR, Voyles J, Misra V. Activation of innate immune-response genes in little brown bats (Myotis lucifugus) infected with the fungus Pseudogymnoascus destructans. 2014. PLoS One 2014 12;9(11):e112285.
Khan MI-U-R, Caminha Faustino Dias F, Dufort I, Misra V, Sirard M-A, Singh J. Stable reference genes in granulosa cells of bovine dominant follicles during follicular growth, FSH stimulation and maternal aging. 2014. Reprod Fertil Dev Nov 27. Epub 2014 Nov 27
Eliott K, MacDonald V, Linn K, Simko E and Misra V. Increase in transcripts for components of the unfolded protein response (UPR) in spontaneous canine tumours. 2014. Can J Vet Res 2014 Jul;78(3):161-7
Ying Z, Zhang R, Verge VMK, Misra V. Cloning and characterization of rat Luman/CREB3, a transcription factor highly expressed in nervous system tissue. 2014. J. Mol. Neurosci. DOI 10.1007/s12031-014-0330-7. [Impact factor 2.89]
Wilcox A, Warnecke L, Turner J, McGuire LP, Jameson JW, Misra V, Bollinger TC, and Willis CKR. Behaviour of hibernating little brown bats experimentally inoculated with the pathogen that causes white-nose syndrome. 2014. Animal Behaviour 88:157-164. [Impact factor 3.07]
Zhang R and Misra V. Effects of cAMP response element binding protein-Zhangfei (CREBZF) on the unfolded protein response and cell growth are exerted through the tumor suppressor p53. 2014. Cell Cycle 13:1-14 [Impact factor 5.00]
Zhang R, Rapin N, Ying Z, Shklanka E, Bodnarchuk T, Verge VMK and Misra V. Zhangfei/CREBZF – a potential regulator of the Unfolded Protein Response. 2013. PLoS One 8(10):e77256 [Impact factor 3.5]
Warnecke L, Turner JM, Bollinger TK, Misra V, Cryan PM, Blehert DS, Wibbelt G, Willis CK. 2013, Pathophysiology of white-nose syndrome in bats: a mechanistic model linking wing damage to mortality. Biol Lett. 2013 May 29;9(4):20130177. doi: 10.1098/rsbl.2013.0177. [Impact factor: 3.25]
Bodnarchuk TW, Napper S, Rapin N, and Misra V. Mechanism for the induction of cell death in ONS-76 medulloblastoma cells by Zhangfei/CREB-ZF. J. Neurooncol. 2012. 109:485-501.
Warneke L, Turner JM, Bollinger TK, Lorch JM, Misra V, Cryan P, Wibbely G, Blehert DS and Willis CKR. Inoculation of bats with European Geomyces destructans supports the novel pathogen hypothesis for the origin of white-nose syndrome. Proc. Natl. Acad. Sci. U.S.A. 2012. 109: 6999- 7003.
Bergeron T, Zhang R, Elliot K, Rapin N, MacDonald V, Linn K, Simko E. and Misra V. The Effect of Zhangfei on the Unfolded Protein Response and growth of cells derived from canine and human tumours. Vet. And Comp. Oncology 2012. Doi:10.1111/j.1476-5829.2011.00310.x.
Articles submitted for publication:
Banerjee A, Rapin N, Miller M, Griebel P, Zhou Y, Munster V, Misra V. Generation and characterization of Eptesicus fuscus (Big Brown bat) kidney cells immortalized using Myotis polyomavirus T-antigen. Submitted, May 2016, J. Virol. Methods.
Rapin N, Banerjee A, Warnecke L, Turner JM, Bollinger TK, Willis CKR, Voyles J, Misra V. Experimental infection of bats with P. destructans (White Nose syndrome fungus) increases replication of naturally persisting coronavirus. Submitted Jan 2016.
Davy CM, Donaldson ME, Kyle CK, Saville BJ, McGuire L, Mayberry H, Wilcox A, Wibbelt G, Misra V, Bollinger T, Willis CKR. Context-dependent interaction between bats and the causative agent of white-nose syndrome. Submitted Jan 2016