Dr. Singh's research interests are centered on the use and further development of the bovine model of maternal reproductive aging for the study of ovarian function in humans. His current and past research has been directed towards studying the ultrasonographic, morphologic and biochemical kinetics and endocrine control of ovarian follicles. He focuses on to investigate the developmental competence of oocytes contained in these follicles for refining controlled breeding programs in cattle and assisted reproduction in humans. His particular interest is in direct in vivo imaging of cumulus oocyte complexes using ultrasound biomicroscopy, echotexture analysis, and 3D visualization of cellular organelles in oocytes. Recently, his research group has examined the role of alterations in granulosa cell transcriptome during follicular and maternal aging. His research program has been funded by the discovery grants from the Natural Sciences and Engineering Research Council of Canada for the past 15 years and by support from the Canadian Foundation for Innovation, Canadian Light Source, EmbryoGENE Network, Prostate Canada, Sylvia Fedoruk Centre for Nuclear Innovation, Saskatchewan Agriculture Development Fund, and Saskatchewan Health Research Foundation. He has published more than 100 original research articles or review papers in scientific journals, 150 abstracts and presented more than 20 Invited talks. His recent research interests include the study of neuroendocrine control pathways in the bovine hypothalamus, follicle development and oocyte competence during pre- and peripubertal period, and the development of domestic animal models for the study of endometriosis in women and benign prostatic hyperplasia in men. His research group maintains the Oocyte Competence Laboratory and the Molecular and Live-cell imaging facility at the western College of Veterinary Medicine.
Adams GP, Singh J (2015) Ovarian follicular and luteal dynamics in cattle (Book Chapter) In Bovine Reproduction Ed. Hopper RM, pp 219-244 first Edn. John Wiley & Sons Inc. IOWA USA
Dias FCF, Khan MIR, Adams GP, Sirard MA, Singh J (2014) Granulosa cell function and oocyte competence: Super-follicles, super-moms and super-stimulation in cattle Animal Reproduction Science 149: 80-89.
Dadarwal D, Honparkhe M, Dias FCF, Alce T, Lessard C, Singh J (2014) Effect of superstimulation protocols on nuclear maturation and distribution of lipid droplets in bovine oocytes Reproduction, Fertility and Development doi.10.1071/RD13265
Dias FCF, Khan MI, Sirard MA, Adams GP, Singh J (2013) Differential gene expression of granulosa cells after ovarian superstimulation in beef cattle Reproduction 146: 181–191
Malhi PS, Adams G and Singh J (2005) Bovine Model for the Study of Reproductive Aging in Women: Follicular, Luteal and Endocrine Characteristics Biology of Reproduction 73: 45-53.
Singh J, Pierson R A and Adams G P (1997) Ultrasound image attributes of the bovine corpus luteum: structural and functional correlates Journal of Reproduction and Fertility 109: 35-44.