Adjuvants are essential components of vaccines because of their immunostimulatory properties. Inactivated and subunit vaccines are considered safe, but are less immunogenic than live vaccines, therefore a crucial need for the development of safe and effective novel adjuvants exists. Polyphosphazenes: Poly[di(carboxylatophenoxy) phosphazene] (PCPP), and poly[di(sodiumcarboxylatoethylphenoxy) phosphazene] have recently been demonstrated to beneficial for the clearance of a broad range of viral and bacterial infections. We hypothesize that the adjuvant properties of the polyphosphazenes are due to signaling through the NOD-Like Receptors (NLRs), which leads to the activation of immune cells. The goal of my research is to investigate the mechanism of action of this adjuvant in porcine immune cells, which will hopefully contribute to the development of novel vaccines future veterinary and human use.