University of Saskatchewan

Western College of Veterinary Medicine

Rui Zhang

Graduate Student, Virology and Molecular Biology
Veterinary Microbiology
Office Location: WCVM 2670
Phone: (306) 966-7214
Email: ruz248@mail.usask.ca


Profile


Academic Credentials


Research Interests

Zhangfei is a basic region–leucine zipper (bZIP) transcription factor, which has been implicated in the differentiation and death of different tumor cells. We also found, Meanwhile, Zhangfei can simultaneously turn off the three arms of the unfolded protein response (UPR) in D-17 canine osteosarcoma cells.

We are presently investigating the effect of transcription factor Zhangfei on dog cancer cells and the molecular mechanism responsible.  We will use various dog cancer cell lines and spontaneous dog tumor cells to test the hypothesis that: Zhangfei can prevent the viability and growth of canine tumors cells and/or the development of resistance to hypoxia, radiation and chemotherapeutic drugs through inhibiting the unfolded protein response (UPR) or other molecular mechanism.