University of Saskatchewan

Western College of Veterinary Medicine

Zhou, Yan

Adjunct Professor
Veterinary Microbiology
Office Location: Room 131, Vaccine and Infectious Disease Organization (VIDO)
Phone: 306-966-7716 or 306-966-1529
Email: yan.zhou@usask.ca


Profile

Dr. Zhou is a Scientist and Project Leader (influenza) at the Vaccine and Infectious Disease Organization (VIDO).

Academic Credentials


Research Interests

Molecular biology, pathogenesis and vaccine development of influenza virus.

Publications

Masic, A. Booth, J. S. Mutwiri, G. K. Babiuk, L. A. Zhou, Y. (2009), Elastase-dependent live attenuated swine influenza A viruses are immunogenic and confer protection against swine influenza A virus infection in pigs, J Virol, 10198-210

Masic A, Babiuk LA, Zhou Y. 2009. "Reverse genetics generated elastase-dependent swine influenza viruses are attenuated in pigs." Journal of General Virology. 90: 375-385.

Oem, J. K. Jackel-Cram, C. Li, Y. P. Zhou, Y. Zhong, J. Shimano, H. Babiuk, L. A. Liu, Q. (2008), Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2, J Gen Virol, 1225-30.

Oem, J. K. Jackel-Cram, C. Li, Y. P. Kang, H. N. Zhou, Y. Babiuk, L. A. Liu, Q. (2008), Hepatitis C virus non-structural protein-2 activates CXCL-8 transcription through NF-kappaB, Arch Virol, 293-301.

Li Y, Anderson DH, Liu Q, Zhou Y. 2008. "Mechanism of influenza A virus NS1 protein interaction with the p85beta , but not the p85alpha, subunit of PI3K and upregulation of PI3K activity." Journal of Biological Chemistry. 283(34):23397-409.

Zhou, Y. Ficzycz, A. Tikoo, S. K. (2007), Porcine adenovirus type 3 E1B large protein downregulates the induction of IL-8, Virol J, 60.

Shin YK, Li Q, Anderson DH, Babiuk LA, Zhou Y. 2007. "SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation." Journal of Virology. 81(23):12730-9.

Shin YK, Liu Q, Tikoo SK, Babiuk LA, Zhou Y. "Effect of PI3K/Akt pathway on influenza A virus propagation." 2007. Journal of General Virology. 88:942-950.

Shin YK, Liu Q, Tikoo SK, Babiuk LA, Zhou Y. 2007. "Influenza virus activates PI3K /Akt pathway by direct interaction of NS1 with p85 subunit of PI3K." Journal of General Virology. 88:13-8.

Oem, J. K. Xiang, Z. Zhou, Y. Babiuk, L. A. Liu, Q. (2007), Utilization of RNA polymerase I promoter and terminator sequences to develop a DNA transfection system for the study of hepatitis C virus internal ribosomal entry site-dependent translation, J Clin Virol, 55-9.