University of Saskatchewan

Western College of Veterinary Medicine

Kryworuchko, Marko

Assistant Professor
Veterinary Microbiology
Office Location: WCVM 2605
Phone: 306-966-7433
Fax: 306-966-7244
Email: Marko.Kryworuchko@usask.ca


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**CURRENTLY RECRUITING UNDERGRADUATE AND GRADUATE STUDENTS, PLEASE INQUIRE**


Academic Credentials


Research Interests

KEYWORDS: Veterinary and human infectious disease pathogenesis; development of novel therapeutics and vaccines; chronic HIV infection; autophagy and apoptosis; monocytes/macrophages, dendritic cell, and cytotoxic T cell differentiation, proliferation, function and survival; cytokines; signal transduction


Publications

Alhetheel, A., Elsageyer, M., Kumar, A., and Kryworuchko, M.  Differential control of human monocyte programmed cell death by IFN-γ and IL-10 via autophagy. In preparation.

Benoit, A., Saxena, M., Saad, A., Kumar, A., and Kryworuchko, M. Functional role of growth factor independent -1 (GFI1) in primary human CD8 T lymphocytes: transcriptional repression and proliferative induction. In preparation.

Saxena, M., Busca, A., Pandey, S., Kryworuchko, M., and Kumar, A. HIV vpr interferes with the TLR-4-activated MyD88 and the calcium signaling pathways to block the induction of anti-apoptotic c-IAP genes and resistance to apoptosis. In preparation.

Saxena, M., Busca, A., Pandey, S., Kryworuchko, M., and Kumar, A. 2011 CpG protects human monocytic cells against HIV-vpr-induced apoptosis by c-IAP-2 through the calcium-activated JNK pathway in a TLR-9 independent manner. J. Immunol. Accepted.

Mishra, J., Benoit, A., Gee, K., Kryworuchko, M., and Kumar, A. 2011. STAT6 is a novel regulator of CD44 expression in human B cells. J. Biol. Chem. Revisions in progress.

Benoit, A., Abdkader, K., Sirskyj, D., Alhetheel, A., Sant, N., Diaz-Mitoma, F., Kumar A., and Kryworuchko, M. 2009. Inverse association of repressor Gfi-1 with CD8 T cell IL-7Rα expression and limited STAT signaling in response to IL-7 among γc cytokines in HIV patients. AIDS. 23(11):1341-7.

Busca, A., Saxena, M., Kryworuchko, M., and Kumar, A. 2009. Anti-apoptotic Genes in the Survival of Monocytic Cells During Infection. Current Genomics. 10(5): 306-317.

Alhetheel, A., Yakubtsov, Y., Abdkader, K., Sant, N., Diaz-Mitoma, F., Kumar, A., and Kryworuchko, M. 2008. Amplification of the STAT1 signaling pathway and its association with apoptosis in monocytes from HIV-infected patients. AIDS. 22: 1137-1144.

Sirskyj, D., Kumar, A., Theze, J., and Kryworuchko, M. 2008. Disruption of the γc cytokine network in T cells during HIV infection. Cytokine. 43: 1–14.