Picture of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    Dr. Suresh Tikoo

Dr. Suresh Tikoo Professor and Director Vaccinology and Immunotherapeutics Program

Research areas

  • Molecular virology
  • Viral pathogenesis
  • Virus-host interactions
  • Vaccinology
  • Mucosal immunization
  • Viral vectors
  • Dendritic cell vaccines

Current research

  • Our studies are focused on understanding how DNA viruses including non human adenoviruses interact with host and produce progeny virions. A major focus of the laboratory is to develop and use non human adenoviruses for vaccination of animals and humans. My current areas of research include:
  • Molecular characterization of non human adenoviruses
  • Non human adenovirus as a vaccine delivery vector
  • Targeted animal adenovirus
  • Adenovirus DNA packaging
  • Protein-Protein interactions
  • Role of structural \ non structural proteins in viral replication

Recent grants and awards

Federal granting agencies:

2015-2017 Co-I Canadian International Food Security Research Fund, Livestock Vaccines Against Viral Diseases for Developing Farmers in sub‐Saharan Africa ($820500 / 30 month)

2014-2019 PI Natural Science and Engineering Council of Canada, “Characterization of Non structural proteins of bovine adenovirus-3” ($265,000\5 yrs)

2012-2015 Co-I Natural Science and Engineering Council of Canada ”Prevention of inclusion body hepatitis (IBH)in the broiler chicken industry: Optimizing two prototype Fowl adenovirus Vaccines,” (156000/3yrs)

2011-2015 Co-I Natural Science and Engineering Council of Canada "Formulation and delivery of immunostimulatory oligo-deoxynucleotides containing CpG motifs (CpG-ODN) with carbon nanotubes (CNTs) against poultry
diseases." ($132198/4 yrs)

Provincial granting agencies:

2015-2017 Co-I Saskatchewan Agriculture Development fund "Interference of maternal immunity and Marek’s disease vaccine in performance of newly develop inclusion body hepatitis vaccines ($100200\2 years)

2015-2017 CO-I SCIDF "Interference of maternal immunity and Marek’s disease vaccine in performance of newly develop inclusion body hepatitis vaccines ($22000\2 years)

2014-2016 Co-I Alberta Livestock and Meat Agency (ALMA) "Development of a vaccine for protection of piglets from porcine epidemic diarrhea virus (PEDV) ($249750/18 months)

2013-2016 PI Saskatchewan Agriculture Development fund “Development of control strategy for porcine respiratory & reproductive syndrome disease”.

Current courses

  • VACC 801.3 – Vaccinology & Immunotherapeutics (Team taught course)
  • VTMC 833.3 – Advanced Virology (Team taught course)
  • VTMC 830.3 – Recent Advances in Microbiology (Team Taught course)

Select publications

Brownlie R, P. Kumar, L. A. Babiuk and Suresh K Tikoo*. (2015) Recombinant Bovine Adenovirus -3 Co-Expressing Bovine Respiratory Syncytial Virus Glycoprotein G and Truncated Glycoprotein gD of Bovine Herpesvirus-1 Induce Immune Responses in Cotton Rats. Molecular Biotechnology 57:58-64

Kulshreshtha V, L. E. Ayalew, A. Islam and Suresh K. Tikoo* (2014). Conserved arginines of BAdV-3 33K protein are important for transportin 3 mediated transport and virus replication”. PLOS1 14 Jul; 9(7):e101216

Dar, Arshud , Suresh K Tikoo, Andy Potter, Lorne A. Babiuk, Volker Gerdts and George Mutwiri. 2014 CpG-ODNs induced changes in cytokine/chemokines genes expression leading to suppression of infectious bronchitis virus replication in chicken lungs. Vet. Immunol. ImunoPathol. 160:209-217.

Anand, SK, J. Singh, A. Gaba and Suresh K. Tikoo* (2014). Effect of bovine adenovirus-3 on mitochondria. Veterinary Research 45:45.

Kumar, P., Ayalew L. E., Godson, D. L., Gaba A., Babiuk, LA, and S. K. Tikoo* (2014). Mucosal immunization of calves with recombinant bovine adenovirus-3 coexpressing truncated form of bovine herpesvirus-1 gD and bovine IL-6. Vaccine 32:3300-3306

Truong, T, Hani Boshra, Carissa Embury-Hyatt1, Charles Nfon, Volker Gerdts, Suresh K Tikoo, Lorne A. Babiuk, Pravesh Kara, Arshad Mather, David Wallace, Shawn Babiuk (2014). Tissue tropism and pathogenesis of peste des petits ruminants virus in sheep and goats following experimental infection PLOS ONE e87145

Anand, S., Amit Gaba, Jaswant Singh and Suresh K Tikoo* (2014) Bovine adenovirus-3 pVII localizes to mitochondria and modulate ATP synthesis, mitochondrial CA2+ and mitochondrial membrane potential. Journal of General
Virology 95:442-452.