Toxicology Group

The Toxicology Group is an interdisciplinary body under the umbrella of the College of Graduate Studies and Research. It consists of faculty members from a number of University departments, as well as scientists from various research centres on campus. The Toxicology Group is coordinated and managed by the Toxicology Centre. Scientists with academic or research interests in toxicology, who work at the University of Saskatchewan or any of the federal or provincial agencies or private sector laboratories on or near campus, are eligible to become members of the Group. Two types of membership may be granted: members are those currently involved in research or teaching specifically related to toxicology; associate members are those who have a principal interest in toxicology, but are not presently engaged in active research or teaching in the field of toxicology.

The mandate of the Group is to: maintain and support academic programs in toxicology at the University of Saskatchewan; promote and facilitate research in toxicology; promote public awareness and engage in community consultation on important issues in the area of toxicology; and to work cooperatively and collaboratively with all academic units participating in toxicology and address difficulties when they arise in matters involving shared resources. The Group is headed by a Chair, who is the Director of the Toxicology Centre, or his or her designate. The Chair is assisted by an Executive Committee, elected every three years by the membership. The Executive Committee consists of an Academic Coordinator, two members-at-large elected by the membership, one member-at-large elected by the Toxicology Centre, and the Dean, College of Graduate Studies and Research (ex officio). Members of the Toxicology Group are eligible to serve as supervisors for students enrolled in M.Sc. and Ph.D. programs in Toxicology. They are actively engaged in research across a broad spectrum of toxicology sub-disciplines. The following is a brief description of Toxicology Group members' primary research interests within sub-disciplines of toxicology.

Academic and Research Faculty

Analytical and Forensic Toxicology

George, G.
Heavy metal and metalloid chemical toxicology using synchrotron based spectroscopic probes and imaging methods. Metalloprotein active site structure and function, and toxic effects due to metal ion dyshomeostasis.
Headley, J.
Environmental mass spectrometry. (Environment Canada)
Pickering, I.
Synchrotron speciation and microscopic localization of metals and metalloids in environmental and human toxicology.

Biomedical and Human Toxicology

Alcorn, J.
Infant exposure to xenobiotics; maturation of clearance mechanisms; toxicokinetics.
Bharadwaj, L.
Drinking water quality and public health, Community-based participatory research, Water regulations and First Nations Health Equity and Promotion, Human and Environmental Risk Assessment.
Blakley, P.
Clinical teratology; Fetal Alcohol Syndrome; genetic predisposition to teratogenesis.
Krol, E.
Xenobiotic metabolism of naturally occuring phenols; reactive intermediates.
Krone, P.
Endocrine modulation/developmental toxicology; use of stress proteins as biomonitors of toxicity in fish embryos.
Paterson, P.
Biochemical and physiological functions of trace elements; nutrition and eye function; effects of nutrients on antioxidant pathways in stroke.
Nazarali, A.
Teratogenicity; DNA-protein interactions; transcriptional factors; expression of developmental genes in mice embryos.
Weber, L.
Tobacco smoke and air pollution effects on cardiovascular disease; pathophysiological mechanisms, animal models, role of polycyclic aromatic hydrocarbon.
Xiao, W.
Mechanisms of action of genotoxic chemicals and cellular responses to DNA damage.
Zello, G.A.
Protein and amino acid metabolism in humans and animals investigated using stable isotope methodology; effects of drugs on protein metabolism, drug-nutrient interactions.

Veterinary and Wildlife Toxicology

Blakley, B.
Immunotoxicology - environmental aspects, nutritional states; applied veterinary toxicology; heavy metal toxicity (Pb, Cd).
Morrissey, C.
Avian ecology and ecotoxicology. Testing biomarkers of exposure (ecophysiological, stable isotopemethods) and effects of pollutants in wild birds.
Wickstrom, M.
Effects of pesticides and metals in wildlife; cyanobacterial toxins; clinical veterinary toxicology; environmental risk assessment.

Ecological and Aquatic Toxicology

Davies, J-M.
Nutrient impacts on algal ecology; drinking water quality. (Water Security Agency)
Giesy, J.
Discovery and assessment of emerging contaminants of concern, including perfluorinated and endorcrine modulating compounds.
Hecker, M.
Development, validation and application of novel bioanalytical techniques; endocrine disruption and reproductive toxicology in oviparous vertebrates.
Hogan, N.
Immune toxicology and disease emergence in fish and amphibians, Endocrine regulation of development and disruption by environmental contaminants.
Haakensen, M.
Environmental microbiology; biogeochemistry; impacts of constructed wetlands on toxicology; microbial ecology (including metagenomics); bioremediation; biodegradation
Janz, D.
Reproductive physiology and endocrinology of oviparous vertebrates; endocrine toxicity; biochemical toxicology; mechanisms of toxicity; cytochrome P450.
Jardine, T.
Comparison of mercury and selenium biomagnification rates through aquatic food webs at local and global scales, Investigations of hydrological and food-web connectivity between rivers and floodplains in Australia’s wet-dry tropics.
Jones, P.
Fate and effects of organic pollutants in the evironment and wildlife. Use of biochemical and molecular biology techniques in environmental toxicology.
Liber, K.
Metal bioavailability and toxicity in aquatic ecosystems, especially in sediments; mining impacts on aquatic ecosystems.
Niyogi, S
Assessment of waterborne metal bioavailability and toxicity using the Biotic Ligand Model (BLM) approach; uptake, regulation, and toxicity of dietary metals in freshwater fish.
Raine, J.
Developmental physiology and endocrinology; endocrine disruption; mechanisms of toxicity; thyroid hormone regulation and signaling.
Siciliano, S.
Soil ecotoxicology, investigation of trace contaminant effects in northern terrestrial ecosystems using molecular tools.
Stewart, K.
Herbicide persistence and toxicity on northern boreal Rights-of-Way Soil amendment technology and practices for remediation and restoration of plant-soil systems impacted by hydrocarbons and heavy metals Biological soil crusts and native vascular plants for restoration of alpine, boreal and arctic ecosystems Identify and restore pathways that promote long-term ecosystem health in northern terrestrial systems