BIOCH 200.3
Molecules of Life
1/2(3L)
Prerequisite(s): Biology 30 or 3 credit units of university-level biology, and CHEM 112. CHEM 250 recommended.

Topics include: simple and complex biomolecules, amino acids, peptides, proteins, carbohydrates, lipids, nucleic acids, coenzymes, vitamins. An introduction to the structure of biological membranes, solute transport, DNA replication, mRNA transcription and protein synthesis will be presented.

BIOCH 207.2
Veterinary Biochemistry
Q1&2(2L-2P)
Prerequisite(s): Registration in the D.V.M. Program or permission of the instructor.

Selected biochemical topics with special relevance to function at the level of the whole organism will be presented. The emphasis will be placed on comparative metabolic aspects of the major food and companion animal species, especially those metabolic differences which occur that are related to performance, productive capacity, and disease processes.

BIOCH 211.3
Introductory Metabolism
2(3L)
Prerequisite(s): BIOCH 200.

Introduction to the thermodynamic aspects of energy metabolism and the principles of anabolic and catabolic metabolic pathways. Emphasis will be placed on the overall purposes of the major pathways, the precursor molecules leading into these pathways, important products, and the basic types of control that regulate metabolic flux.

BIOCH 212.3
Introductory Biochemical Techniques
2(3L/4P)
Prerequisite(s): BIOCH 200.

The theory, application and practice of basic biochemical techniques used in all life science and biotechnology disciplines is presented. Topics include: buffer preparation, pH determination, spectrophotometric methods, enzyme measurement, chromatography, radioisotopes, and methods for the characterization and separation of amino acids, sugars, lipids, proteins, enzymes, and DNA such as ultra centrifugation, chromatography and electrophoresis.

BIOCH 213.8
Medical Biochemistry & Nutrition
Prerequisite(s): Restricted to students enrolled in the College of Medicine.

Reviews the structure and function of biomolecules, organization and general principles of metabolism, production and utilization of energy, and replication and expression of genetic information. Selected topics in human nutrition will be reviewed, including nutritional assessment, diet and physiological status, primary nutritional diseases, nutritional considerations in other diseases, and public health aspects of nutrition. The use of biochemical knowledge in the investigation and management of human disease will be emphasized through a case-oriented approach.

BIOCH 220.3
Introductory Plant Biochemistry
1(3L)
Prerequisite(s): BIOCH 200 or BIOL 110, and CHEM 251.

This introduction to plant biochemistry presents the following: photosynthesis, respiration, and energy generation; nitrogen, carbohydrate, lipid, and some secondary metabolism. The emphasis will be on metabolic events that are typical of plants, and often different from other living organisms.

BIOCH 230.3 (Formerly 300)
Information Transfer - DNA to Proteins
2(3L)
Prerequisite(s): BIOCH 200.

Deals with the structure and function of nucleic acids at an advanced level. Chromosome anatomy, DNA replication, transcription of genes, and translation of mRNA in both prokaryotes and eukaryotes are covered. The various mechanisms whereby gene expression is regulated are also discussed.

BIOCH 310.3
Proteins and Enzymes
1(3L/4P)
Prerequisite(s): BIOCH 212; CHEM 250 and permission of the department. Preference will be given to students in biochemistry programs..

The properties of proteins and enzymes will be described including structure, kinetics, regulation and modification, antibodies, membrane proteins and glycosylation. Laboratories will provide experience with the determination of structural and functional properties including: ultracentrifugation, chromatography, electrophoresis, kinetics, phosphoamino acid identification, Western blotting, computer-based sequence analysis via the Internet.

BIOCH 311.3
Introductory Molecular Biology
1(3L/4P)
Prerequisite(s): BIOCH 212, CHEM 250, and one of BIOCH 230, BIOL 211, or MICRO 216 and permission of the department. MICRO 214 or AP MC 212 recommended. Preference will be given to students in the biochemistry programs.

Basic principles and techniques of nucleic acid manipulations used in molecular biology and biotechnology are presented. Information and practical experience with plasmids, restriction endonucleases, PCR, DNA sequencing, site-directed mutagenesis, cloning, hybridization, analysis of RNA and gene promoters, and protein over-expression are presented. The laboratory component will also include an Internet exercise.

Note: Students cannot obtain credit for this course and MICRO 391 (395).

BIOCH 412.3
Protein Structure, Function, and Engineering
2(3L)
Prerequisite(s): BIOCH 310 and CHEM 250.

The details of protein structure, domains, folding and targeting, and modern experimental approaches to protein engineering will be presented. The inter-relationship between structure and function in enzyme/protein mechanism and regulation shall be stressed.

Note: This course will be offered in the academic year 2003/2004 and alternate years thereafter (2005/2006, etc.).